Recently Weinstein (12) presented evidence that the susceptibility of enterococci to the carbapenem imipenem could be predicted using the MICs of either ampicillin or penicillin. The current susceptibility testing interpretive tables (9, 10) of the National Committee for Clinical Laboratory Standards (NCCLS) do not list imipenem among the agents (amoxicillin with or without clavulanic acid, amp...

Imipenem was found to inhibit Proteus vulgaris beta-lactamase in a progressive manner. Kinetic experiments confirmed that the inactivated enzyme was not completely recovered after intact imipenem had been exhausted.

Burn injury and wound is a pig problem that assists the pathogens to grow cause infection. 149 burninjury swabs were taken from different site of patients’ body ages (11-53 years old). All samples weretested isolate sigificant microorganisms found in burn injury. Antibiotics test was performed byusing disc diffusion way stated by Kirby-Baucer. Results appeared most frequent pathogen inburn Pseu...

Sir Hospital-acquired infections in critically ill patients remain one of the most important contributors to morbidity and mortality. Hospital-acquired A. baumannii has emerged as a serious threat to ICU patient population. The main purpose of our study was to determine the incidence of ICU acquired imipenem-resistant A. baumannii and its impact on ICU mortality. This prospective study was carr...

Intravenously administered ciprofloxacin was compared with imipenem for the treatment of severe pneumonia. In this prospective, randomized, double-blind, multicenter trial, which included an intent-to-treat analysis, a total of 405 patients with severe pneumonia were enrolled. The mean APACHE II score was 17.6, 79% of the patients required mechanical ventilation, and 78% had nosocomial pneumoni...

Nonfermenting gram negative bacilli (NFGNB) cause serious infections in immuncompromised and hospitalized patients. They cause fatal lower respiratory tract infections in patients admitted to ICU’s. The appearance of metallo ß-lactamases (MBL) genes and their spread among bacterial pathogens is a matter of concern. The present study was undertaken to know the prevalence of MBL producing NFGNB.N...

This study explored the evolutionary mechanism by which the clinical isolate PA110514 yields the imipenemresistant derivative PA116136. Both isolates were examined by PFGE and SDS-PAGE, which led to the identification of a new insertion sequence, ISPa133. This element was shown to have distinct chromosomal locations in each of the original isolates that appeared to explain the differences in im...

A three-pronged cost-effectiveness analysis of the treatment of febrile episodes in neutropenic cancer patients was conducted. It included a review of 37 randomized, controlled studies in the MEDLINE and EMBASE databases (1980-1996). Clinical outcomes as well as costs of treatment with imipenem/cilastatin, ceftazidime and ceftriaxone + aminoglycoside were compared. Primary therapy and modificat...

UNLABELLED In the study we tested drug sensitivity to 3 carbapenems (doripenem, imipenem and meropenem) of Gram-negative clinical isolates from Southern Poland. MATERIAL AND METHODS 89 strains were examined: 42 from Pseudomonas genus, 16 Acinetobacter baumannii strains and 31 Enterobacteriaceae strains. Etests were used according to the producers instructions, MIC values were interpreted usin...

After ertapenem was added to the formulary of a 344-bed community teaching hospital, we retrospectively studied its effect on antimicrobial utilization and on the in vitro susceptibility of various antimicrobial agents against Pseudomonas aeruginosa. Three study periods were defined as preintroduction (months 1 to 9), postintroduction but before the autosubstitution of ertapenem for ampicillin-...