Most of the major innovations in evolution occurred at the very beginning of life on this earth some 3.5 billion years ago before the division of eukaryotes from prokaryotes. This initial innovativeness was due, in no small part, to the peculiar construction of primordial coding sequences that were repeats of base oligomers, the number of bases in oligomeric units not being a multiple of three....

Immortality is an essential characteristic of cancer cells; a recent transcriptomic study of epithelial cell immortalization has linked epigenetic silencing of the long noncoding RNA Mortal Obligate RNA Transcript (MORT; alias ZNF667-AS1) to this process. This study evaluated the epigenetic and transcriptional state of MORT in two premalignant conditions-ductal carcinomas in situ and colon aden...

This study presents a psychoanalytical reading of Coleridge’s “Kubla Khan” having an eye on Žižek’s theory the subject. contains host components providing illustration psychological status. In such case, Žižekian approach to psychoanalysis could provide suitable paradigm for analytical poem. The works Žižek conducted disputatious re-articulations subject/object, displacement objet petit (object...

Recent work in developmental psychology indicates that children naturally think that psychological states continue after death. One important candidate explanation for why this belief is natural appeals to the idea that we believe in immortality because we can’t imagine our own nonexistence. This paper explores this old idea. To begin, I present a qualified statement of the thesis that we can’t...

The Eighth Annual Pezcoller Symposium focused on the mecha nism of genetic instability, a characteristic of neoplastic cells that also determines tumor progression. Immortality as a consequence of the lack of susceptibility to mechanisms of maturation, senescence, and/or apoptosis was also discussed because it is another pivotal character istic of the neoplastic cell. Mutational lability, chang...

1. Serial transplantation of tumors made it possible in 1901 and following years to draw the conclusion that various mammalian tissues have potential immortality. Serial transplantations of normal tissues did not succeed at first, because the homoioreaction on the part of the lymphocytes and connective tissue of the host injures the transplant. 2. In continuation of these experiments we found t...

Cellular senescence is a process leading to terminal growth arrest with characteristic morphological features. This process is mediated by telomere-dependent, oncogene-induced and ROS-induced pathways, but persistent DNA damage is the most common cause. Senescence arrest is mediated by p16(INK4a)- and p21(Cip1)-dependent pathways both leading to retinoblastoma protein (pRb) activation. p53 play...