نتایج جستجو برای: immunological responses
تعداد نتایج: 428517 فیلتر نتایج به سال:
BACKGROUND Antigen-specific anti-tumor vaccines have demonstrated clinical efficacy, but immunological and clinical responses appear to be patient-dependent. We hypothesized that naturally-occurring differences in amino acid sequence of a host's target antigen might predict for immunological outcome from genetic vaccination by presentation of epitopes different from the vaccine. METHODS Using...
The energy metabolism was demonstrated to directly modulate immune cell function and thereby physiological detrimental responses. In addition, the field of immunometabolism is vastly growing. However, yet there remain fundamental scientific questions in field, which require organization national international networks as well implementation into curricula, societies, immunological routine diagn...
SARS-CoV-2 is a member of the coronaviruses family that causes the outbreak of coronavirus disease 2019 (COVID-19) in China in late 2019 which has exploded to a global pandemic. The reference genome of the SARS-CoV-2 is considered to be very closely related to SARS-CoV and the virus uses the ACE-2 receptor for cellular entry similar to SARS-CoV. The most common symptoms of COVID-19 are fever, c...
Tobacco smoking causes a variety of illnesses, the most common which is ''Chronic Obstructive Pulmonary Disease'' (COPD), and has severe influence on one's health.Tobacco consists nearly 7000 toxic chemicals, including free radicals oxidizing agents. The impact research being done both innate adaptive immune responses. Adaptive systems affected by include T helper cells, regulatory memory T/B l...
BACKGROUND Specific cellular cytotoxic immune responses (CTL) are important in combating viral diseases and a highly desirable feature in the development of targeted HIV vaccines. Adjuvants are key components in vaccines and may assist the HIV immunogens in inducing the desired CTL responses. In search for appropriate adjuvants for CD8(+) T cells it is important to measure the necessary immunol...
Events in a sequence may each be evaluated as good or bad. We propose that such good-bad evaluations evoke emotional responses that change current mood. A model of recurrent updating of current mood is developed and compared to a model of how a sequence of events evoking emotional responses is evaluated retrospectively. In Experiment 1, 149 undergraduates are presented sequences of lottery outc...
BACKGROUND Recently, we demonstrated immunological and clinical responses to a RHAMM-R3 peptide vaccine in patients with acute myeloid leukemia, myelodysplastic syndrome and multiple myeloma. To improve the outcome of the vaccine, a second cohort was vaccinated with a higher dose of 1,000 microg peptide. DESIGN AND METHODS Nine patients received four vaccinations subcutaneously at a biweekly ...
Background: Recently, we demonstrated immunological and clinical responses to a RHAMM-R3 peptide vaccine in patients with acute myeloid leukemia, myelodysplastic syndrome (MDS) and multiple myeloma (MM). To improve the outcome of the vaccine, a second cohort was vaccinated with a higher dose of 1,000μg peptide. Design and Methods: Nine patients received four vaccinations subcutaneously at a biw...
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