BACKGROUND Immunosuppressive therapy is reportedly ineffective in adults with acute myocarditis. AIMS To systematically review the impact of immunosuppressive therapy on the outcome of acute myocarditis in children. METHODS A literature search for articles published from 1984 to 2003 was conducted with the following keywords: myocarditis, dilated cardiomyopathy, and immunosuppression. The r...

Background and Aim: Steroid-resistant nephrotic syndrome (SRNS) accounts for 10%-20% of all cases of idiopathic nephrotic syndrome. These patients are at risk of developing end-stage renal disease. The aim of this study was to determine the demographic characteristics, renal biopsy findings, response to immunosuppressive treatment, and prognosis in pediatric patients with SRNS.Materials and Met...

Immunosuppressive agents such as FK-506 and rapamycin inhibit aldosterone- stimulated Na+ transport in A6 cells. Concentration dependence is consistent with the known affinities of these agents for immunophilins. The inhibition was also dependent on time, requiring preincubation with FK-506 or rapamycin before inhibition was seen. The present studies were designed to determine whether this inhi...

Abstract Immunosuppressive ability in human MSC donors has been shown to be variable and may a limiting factor therapeutic efficacy vivo. The importance of cytokine activation mesenchymal stromal cells (MSCs) facilitate their immunosuppressive function is well established. This study sought further understand the interactions between MSCs commonly used calcineurin inhibitor cyclosporine A (CsA)...

Immunosuppressive agents are commonly used in the nephrologist's practice in the treatment of autoimmune and immune-mediated diseases and transplantation, and they are investigational in the treatment of AKI and ESRD. Drug development has been rapid over the past decades as mechanisms of the immune response have been better defined both by serendipity (the discovery of agents with immunosuppres...