HYPOTHESIS Our experience with peristomal ulcers suggested that peristomal pyoderma gangrenosum (PPG) is an infrequent and usually unrecognized complication of inflammatory bowel disease. We hypothesized that a review of our experience with PPG would clarify the essentials of its diagnosis, evaluation, and treatment. DESIGN A case series of 20 consecutive patients with PPG complicating inflam...

Abstract Background and Aims Common Variable Immune Deficiency (CVID) is a primary immunodeficiency disorder, where genetic defects are commonly present, with hypogammaglobulinemia (typically IgG) increased susceptibility to recurrent infections, autoimmune disorders, granulomatous diseases malignancy. It can also potentially lead nephropathy, risk of proteinuria metabolic acidosis, higher acut...

Background: Diagnosis of autoimmune diseases (AD) has been increasing in recent years, with a prevalence 3- 5% worldwide. The causes that lead to an inpatient approach patients suspicion or confirmed rheumatic disease (RD) vary widely. RD are at higher risk infectious, cardiovascular and other comorbidities due immunosuppression, continuous inflammatory state altered immune response, morbidity ...

Background IgG4 related disease (IgG4-RD) is an immune-mediated fibro-inflammatory condition that can mimic malignant, infectious and inflammatory diseases (1). Systemic lupus erythematosus (SLE) a chronic autoimmune characterized by multisystem inflammation autoantibody generation (2). Overlap of IgG4-RD SLE not frequent, however there have been few cases reported with kidney involvement secon...

P roinflammatory changes in the immune phenotype of circulating blood monocytes in acute Charcot in diabetes have recently been described (1), but the effects of immunosuppression have not been investigated. This report describes a modified clinical phenotype for Charcot in three subjects on immunosupression therapy for previous transplantation—two live-related renal and one simultaneous pancre...

Mycobacterium tuberculosis (MTB) is an enormous public health problem. According to recent data, MTB infects some one-third of the world’s population and two million die from the disease annually. The essential task of developing an effective vaccine for MTB will depend upon a fuller understanding of the immune mechanism involved in protection against infection. In this regard, it has long been...

I read with interest the recently published study by O’Brien et al1 on valganciclovir versus valaciclovir in prevention of cytomegalovirus (CMV) reactivation in patients with lymphoid malignancies treated with alemtuzumab-containing regimens. The study was terminated early after enrollment of 40 patients due to CMV reactivation in 7 of 20 patiens on valaciclovir versus 0 of 20 on valganciclovir...

Sir, Acquired von WillebrandÊs Disease (AVWD) is a rare bleeding disorder, usually occurs in elderly patients. We would like to present case with recurrent gastrointestinal bleeding diagnosed to have AVWD with inhibitors. A 63 years male presented with a history of recurrent episodes of lower gastrointestinal bleeding for three years. He had also a history of occasional epistaxis and skin bleed...

The aim of this study was to evaluate methicillin-resistant Staphylococcus aureus (MRSA) bacteremia cases who were followed at the Infectious Diseases Unit of Internal Medicine Department, at Hacettepe University Adult and Oncology Hospitals between January 2004-December 2011. A total of 198 patients, of them 99 had positive MRSA blood cultures (case group), and 99 without MRSA bacteremia (cont...