Cancer immunotherapy is gaining momentum in the clinic. The current challenge is to understand why a proportion of cancer patients do not respond to cancer immunotherapy, and how this can be translated into the rational design of combinatorial cancer immunotherapy strategies aimed at maximizing success of immunotherapy. Here, we discuss how tumors orchestrate an immunosuppressive microenvironme...

The only causative treatment for IgE-mediated allergies is allergen-specific immunotherapy. However, fewer than 5% of allergy patients receive immunotherapy because of its long duration and risk of allergic side effects. We aimed at enhancing s.c. immunotherapy by direct administration of allergen into s.c. lymph nodes. The objective was to evaluate safety and efficacy compared with conventiona...

Immunotherapy has been one of the standard treatment options for lung cancer. Biomarkers such as PD-L1 and TMB have a certain predictive role on efficacy. At same time, studies also found that EGFR mutations ALK fusions were inversely related to efficacy immunotherapy. The MYSTIC trial evaluated STK11, KEAP1, ARID1A, KRAS their correlation with immune results showed STK11 and/or KEAP1 had poor ...

This article, the second in a series of three, provides an overview of the efficacy and safety of cancer immunotherapies ranging from monoclonal antibodies to vaccines, including additional clinical considerations regarding immune checkpoint blockers.

Background Pharmacovigilance studies are helpful to follow the use of allergen immunotherapy in clinical practice. Industrially manufactured allergen vaccines (VALERGEN) of three mite species (including the tropical species Dermatophagoides siboney and Blomia tropicalis) have been recently introduced country-wide in Cuba for asthma treatment. To assess the safety and efficacy of allergen immuno...

Tumor heterogeneity is commonly seen in melanoma patients and a hurdle to effective therapy as illustrated by the “mixed responses” frequently immunotherapy-treated patients. Previously, AXL+ cells were identified be highly resistant targeted therapy, whereas more differentiated MITF+ responded well RAF/MEK inhibitors. This study aimed identify if show intrinsic resistance immunotherapy, these ...

Background When the specific immunotherapy with house dust mite was done in patients who had allergic diseases, change of specific immunoglobulin(Ig)E and IgG4 is well known. But, it is not known whether there is change for specific IgE and IgG4 during initial build-up phase and there is difference for antibody between rush immunotherapy group and conventional immunotherapy group during mainten...

Immunotherapy is a type of cancer treatment that aids your immune system to fight cancer. The helps body infections and other diseases. It made up white blood cells organs tissue the lymph system. uses substance from living organisms treat 1 focuses on boosting body’s own response against tumors. Cancer can be treacherous targets for both therapeutic agent natural defense line But new approach ...

BACKGROUND Several types of T cells have been associated with the pathogenesis of unexplained recurrent spontaneous abortion (URSA), including Th1/Th2/Th17/Tregs cell. It has been appreciated that immunotherapy with paternal or third party lymphocytes is an effective method of treatment for URSA patients. The balance of Th1/Th2 cells could be maintained and an increase of Treg cells would be be...