NEED AND PURPOSE OF REVIEW Subclinical hypothyroidism is a biochemical diagnosis characterized by raised thyroid stimulating hormone and normal free T4, without clinical features of hypothyroidism. This review analyzes the current evidence to arrive at a consensus and algorithm to manage this condition. METHODS We searched Pubmed, Cochrane and Embase for articles published between 1990 to 201...

BACKGROUND AND OBJECTIVES Subclinical hypothyroidism is associated with endothelial dysfunction and impaired coronary flow reserve. However, the effect of subclinical hypothyroidism or thyroid autoimmunity on variant angina has yet to be determined. SUBJECTS AND METHODS Among 385 consecutive patients without associated cardiovascular risk factors who underwent coronary angiography with the er...

BACKGROUND AND PURPOSE Acute cerebral ischemia has been described in different diseases of the thyroid gland, and not only as a result of thyrotoxic atrial fibrillation and cardioembolic stroke. The purpose of this review is to summarize the studies on the relationship between thyroid diseases and cerebrovascular diseases, discussing the main findings for overt hyperthyroidism and hypothyroidis...

OBJECTIVE There is controversy as to whether hypothyroidism increases cardiovascular risk. The effect of levothyroxine on the cardiovascular risk profile is also unclear. Recent studies suggest that there is evidence of inflammation and endothelial dysfunction in hypothyroidism. Soluble CD40 ligand (sCD40L) is a protein expressed mainly by activated platelets which have been found to be associa...

About 30% of children with elevated TSH levels during neonatal screening have a transient form of disorder. On the other hand, it has been reported that subclinical hypothyroidism persists in late childhood in about 30% of children found to be false-positive during neonatal screening. The aim of this study was to determine whether transient thyroid dysfunction and subclinical hypothyroidism det...

OBJECTIVE Subclinical hypothyroidism is an elevation in serum thyroid-stimulating hormone (TSH) while having normal serum free thyroxine (FT4) and triiodothyronine (FT3) levels. The purpose of this prospective observational study was to evaluate the pulmonary function of patients diagnosed with subclinical hypothyroidism, both before and after treatment with thyroid hormone. METHODS This stud...

current study was aimed to evaluating protective effects of cornus mas fruit extract (cmfe) in mice treated with methotrexate (mtx). for this purpose, 48 young mature male mice were divided into 6 groups. control group received only normal saline (0.1 mlper day, intraperitoneally), and the second group was administered mtx (20 mg kg-1 perweek, intraperitoneally). the third, fourth and fifth gro...

objective: to determine bilateral effects of unilateral iatrogenic vas deferens trauma (uit) on epididymal sperm characteristics and in vitro fertilizing capacity in an experimental mouse model. methods: experiments were performed on three equal groups each comprising six adult male mice. following anaesthesia, uit was induced by clamping left vas deferens with a mosquito clamp in fully locked ...

background: in this study, we aimed to investigate the ability of transvaginal doppler ultrasonography in predicting in vitro fertilization (ivf) outcome in women undergoing this procedure. materials and methods: in this prospective observational study, 65 infertile women underwent ivf procedure in isfahan, during 2013-2014, were studied. the pulsatility index (pi), resistive index (ri) and pea...

background: despite major advances in assisted reproductive techniques, the implantation rates remain relatively low. some studies have demonstrated that intrauterine infusion of granulocyte colony stimulating factor (g-csf) improves implantation in infertile women. objective: to assess the g-csf effects on ivf outcomes in women with normal endometrial thickness. materials and methods : in this...