The secondary positron beams produced by linear electron accelerators are used in scattering experiments with stationary targets, in electron-positron colliding beam experiments, and in the production of annihilation photon beams : they now approach primary electron beams in their energy, intensity, and range of application. (To be published in physics Today) Work supported by the U.S. Atomic E...

Cellular and viral microRNAs (miRNAs) are the transcriptional products of RNA polymerase II and are regulated by transcriptional factors for their differential expression. The altered expression of miRNAs in many cancer types has been explored as a marker for possible diagnosis and therapy. We report in this study that oncogenic human papillomaviruses (HPVs) induce aberrant expression of many c...

Berenil, a minor groove DNA binding molecule, has been extensively used in veterinary medicine. Modeling studies have suggested that berenil binds to A/T rich regions on the DNA and the product of this interaction causes the formation of crosslinks between opposite DNA strands. These crosslinks could potentially inhibit fundamental biological processes including transcription and DNA replicatio...

BACKGROUND 22q11.2 microdeletion syndrome is the most common multiple genetic disorder associated with learning disabilities, developmental delays, immune deficiency, hypocalcemia, and cleft palate. Finding some valid criteria for screening of 22q11.2 deletion syndromes in infants would be very helpful in early diagnosis and treatment. MATERIALS AND METHODS Since 69% of individuals with 22q11...

Geant4 Application for Emission Tomography (GATE) is a widely used, well-validated and very versatile application for Monte Carlo simulations in emission tomography. However, its computational performance is poor, especially for voxelized phantoms, partly due to the use of a very general particle tracking algorithm. In this work, two methods are proposed to reduce the time spent on particle tra...

Book review on J. G. Feinberg – I. Landa Mervart (vyd.) Karel Kosík and the Dialectics of Concrete. Leiden Boston (Brill) 2022, 378 str.

This paper summarises and gives an overview of the development of the ΩMEGA system during the 12 years of funding by the SFB 378.

Astaxanthin, a high-value ketocarotenoid is mainly used in fish aquaculture. It also has potential in human health due to its higher antioxidant capacity than beta-carotene and vitamin E. The unicellular green alga Haematococcus pluvialis is known to accumulate astaxanthin in response to environmental stresses, such as high light intensity and salt stress. Carotenoid hydroxylase plays a key rol...