Hypertrophic cardiomyopathy (HCM) is a common inherited cardiac disease that affects the heart muscle with diverse clinical outcomes. HCM can cause sudden cardiac death (SCD) during or immediately after mild to rigorous physical work in young patients. However, the mechanism causing SCD as a result of exercise remains unknown, but exercise-induced ventricular arrhythmias are thought to be respo...

Objective- To compare the effects of xylazine-ketamine and xylazine-thiopental on cardiac rhythm indogs.Design- Experimental study.Animals- 15 mixed-bred, adult dogs of either sex.Procedures- Following premedication with xylazine HCI, either ketarnine HCI or sodium thiopentalwere administered to dogs. Cardiac rhythm was evaluated before as well as 15,30,45, and 60 minutes and3 days after induct...

common congenital cyanotic heart disease, but it can now be treated with very good long term results. It has been known for many years, however, that patients with surgically treated TF are at risk of sudden cardiac death even many years later, while a large number of these patients exhibit postoperative arrhythmias. What is not entirely clear is the relation between ventricular arrhythmias det...

E lectrical activity underlies the control of the frequency, strength, and duration of contraction of the heart. During the cardiac cycle, a regular rhythmic pattern must be established in time-dependent changes in ionic conductances to ensure events that underlie normal cardiac function. Electrical impulses, originating at the sino atrial node are conducted throughout the atria until they conv...

Brugada syndrome is an inherited cardiac condition with the potential for development of life-threatening arrhythmias in relatively young individuals without significant structural cardiac abnormalities. The condition is characterized by a distinct coved-type ST segment elevation in the right precordial leads (V1-V3). This hallmark pattern (type 1) is often dynamic and sometimes concealed, and ...

Incidence and prognostic relevance of supraventricular arrhythmias were evaluated in nine studies. These studies investigated patients with different forms of pulmonary hypertension. Supraventricular arrhythmias were more often found in patients with group two pulmonary hypertension. Common findings in these patients were elevated right atrial pressure and diameters and reduced tricuspid annula...

Drugs often have undesired side effects. In the heart, they can induce lethal arrhythmias such as torsades de pointes. The risk evaluation of a new compound is costly and can take a long time, which often hinders the development of new drugs. Here, we establish a high-resolution, multiscale computational model to quickly assess the cardiac toxicity of new and existing drugs. The input of the mo...

BACKGROUND Hypercholesterolemia protects against ventricular fibrillation in patients with myocardial infarction. We hypothesize that hypercholesterolemia protects against ischemia-induced reentrant arrhythmias because of altered ion channel function. METHODS AND RESULTS ECGs were measured in low-density lipoprotein receptor knockout (LDLr(-/-)), apolipoprotein A1 knockout (ApoA1(-/-)), and w...

ARMOUR, ,J. A., G. R. HAGEMAN, AND W. C. RANDALL. Arrythmias induced by local cardiac nerve stimulation. Am. J. Physiol. 223(5) : 10684075. 1972.-Electrical and mechanical activity were recorded from multiple regions of the canine heart during electrical stimulation of distal portions of individual cardiac nerves. Functional responses included generalized augmentation in contractile force, toge...