A worker with occupational exposure to aluminum powder developed asthmatic symptoms three years and six months after starting work. Skin tests (prick and intradermal) to aluminum chloride (AlCl3) were negative. Inhalation challenge test with 10 mg of aluminum powder and 10 mg/ml of AlCl3 solution induced an early asthmatic response. Sodium cromoglycate pre-treatment reduced AlCl3-induced bronch...

Background. The author examined psychiatrically a group of 106 patients with difficult asthma and 100 patients with aspirin-induced asthma. The special interest of the study were the links between defence mechanisms used by women and men from both groups and severity of their panic symptoms. Methods. 106 consecutive adults with confirmed, physician-diagnosed difficult asthma and 100 patients wi...

Asthma (chronic allergic airways disease, AAD) is characterized by airway inflammation (AI), remodeling (AWR) and hyperresponsiveness (AHR). Current treatments for AAD mainly focus on targeting AI its contribution AHR, with the use of corticosteroids. However, there are no therapies direct treatment AWR, which can contribute to obstruction, AHR corticosteroid resistance independently AI. The ac...

Abstract Asthma is a respiratory disease with dramatically increasing incidence globally. The present study explored the roles of S-phase kinase-associated protein 2 (SKP2) and forkhead box O3 (FOXO3) in asthma their involvement Krüppel-like factor 15–lipoprotein receptor-related 5 (KLF15–LRP5) axis. SKP2 expression patients OVA-induced asthmatic Sprague Dawley rats was detected by reverse tran...

background: asthma is a chronic inflammatory disorder of the airways. the available treatment options have major limitations owing to low efficacy, associated adverse events and compliance issues. therefore, the health burden of bronchial asthma is increasing globally at an alarming rate, providing a strong impetus for the development of new therapeutics. myrica sapida is known traditionally in...

spirometry has been used as a common diagnostic test in asthma. most of the patients with a mild asthma have a fev1 within normal range. hence, other diagnostic methods are usually used. the aim of this study was to evaluate whether eosinophil cationic protein (ecp) could be an accurate diagnostic marker of mild asthma. in this study diagnosis of asthma was made according to internationally acc...

BACKGROUND A study was undertaken to evaluate the reliability of a digital tracheal sound analyser (ELENS-DSA) in predicting nocturnal changes in airways resistance in asthmatic patients. This device allows continuous measurement of the proportion of the time occupied by wheezing (Wh%). METHODS Nocturnal polygraphic studies with simultaneous continuous monitoring of tracheal sounds and airway...

BACKGROUND There is a lack of clinical evidence that annual vaccination against influenza prevents asthma exacerbations in children. METHODS Retrospective cohort study of 800 children with asthma, where one half did, and the other half did not receive the influenza vaccine. The two groups were compared with respect to clinic visits, emergency department (ED) visits, and hospitalisations for a...

We examined the degree of airway obstruction that developed in eight asthmatics who exercised while breathing air under four conditions: (a) ambient room temperature and water content; (b) body temperature and ambient water content; (c) ambient room temperature fully saturated; and (d) body temperature fully saturated. These test conditions were performed in random order. Multiple aspects of pu...

PURPOSE OF REVIEW Numerous clinically relevant allergenic molecules enhance the performance of specific (s) IgE tests and improve the specificity of allergy diagnosis. This review aimed to summarize our current knowledge of the high-molecular-weight allergens involved in the development of occupational asthma and rhinitis and to critically analyze the contribution of component-resolved diagnosi...