Background: Occupational lead poisoning is common in workers of some industries, but lead hepatotoxicity has rarely been reported. Several animal studies have revealed lead induced liver damage but clinical studies concerning the manifestations of lead induced liver toxicity in humans are scares. This study was designed to investigate the clinical manifestations and pathological parameters of h...

Multikinase inhibitors (MKI) are targeted molecular agents that have revolutionized cancer management. However, there is a paucity of data concerning MKI-related liver injury risk and clinical guidelines for the management toxicity in patients receiving MKI scarce. We conducted PubMed search articles English published from January 2000 to December 2018 related hepatotoxicity 29 FDA-approved MKI...

Propylthiouracil (PTU) is often used to produce experimental hypothyroidism. In general, PTU generates hepatotoxicity, albeit with dissimilar incidence rates of hepatotoxicity. This study examined the hepatoprotective effects Saussurea lappa root ethanol extract on experimentally induced hepatotoxicity in female rats. For this study, 25 adult albino rats were placed into five equal groups: cont...

Idiosyncratic drug toxicity refers to toxic reactions occurring in a small subset of patients and usually cannot be predicted during preclinical or early phases of clinical trials. One hypothesis for the pathogenesis of hepatic idiosyncratic drug reactions is that, in certain individuals, underlying inflammation results in sensitization of the liver, such that injury occurs from an agent that t...

Isoniazid (INH), a widely used drug in the prophylaxis and treatment of tuberculosis, is associated with a 1 to 2% risk of severe and potentially fatal hepatotoxicity. There is evidence that the INH metabolite hydrazine plays an important role in the mechanism of this toxicity. Metabolism of INH leads to the production of hydrazine via both direct and indirect pathways. In both cases, the activ...

Cyclosporine A (CsA) is the immunosuppressor which is most frequently used in transplant surgery and in the treatment of autoimmune diseases. Oxidative stress has been implicated as one of the possible mechanisms of CsA-induced hepatotoxicity. The present investigation examined the ability of taurine as an antioxidant to protect against CsA-induced oxidative stress and hepatotoxicity. CsA hepat...

(1) Background: Hepatotoxicity is a common health problem, and oxidative stress plays crucial role in its underlying mechanisms. We inspected the possible effect of retinoic acid (RA) potentiation hepatoprotective bone marrow mesenchymal stem cells (BM-MSCs) against Cisplatin (Cis)-induced hepatotoxicity. (2) Methods: 60 male Sprague Dawley rats (SD) were separated randomly designated to six ma...

background : lindane is an insecticide which is used in commercial insecticides and food containers. caseâ presentation : herein, we reported on a 62-year-old man with liver cirrhosis 12 years after continuous exposure to lindane gas.the diagnostic workup showed no other possible cause, and findings of liver scintigraphy and clinical manifestations were compatible with substance-induced cirrhos...

Acetaminophen (APAP) hepatotoxicity is mediated by N-acetyl- p -benzoquinone imine (NAPQI), a highly toxic metabolite generated cytochrome P450 2E1 (CYP2E1). Thus, pathological conditions increasing CYP2E1 activity can favour APAP-induced liver injury, which characterized massive hepatocellular necrosis and secondary sterile inflammation. In recent work, Wang et al. showed that was exacerbated ...