Various studies showed a clear impairment of cerebellar patients to modulate grip force in anticipation of the loads resulting from movements with a grasped object. This failure corroborated the theory of internal feedforward models in the cerebellum. Cerebellar damage also impairs the coordination of multiple-joint movements and this has been related to deficient prediction and compensation of...

The type I interferon (IFN-I) system is important for antiviral and anticancer immunity. Prolonged activation of IFN/JAK/STAT signaling closely associated with autoimmune diseases. TRIM10 dysfunction may be certain disorders. Here, we observed that the serum protein level lower in patients systemic lupus erythematosus than healthy control subjects. We speculated possible involvement TRIM10-indu...

Pathological lung overdistention associated with mechanical ventilation at high tidal volumes (ventilator-induced lung injury; VILI) compromises endothelial cell (EC) barrier leading to development of pulmonary edema and increased morbidity and mortality. We have previously shown involvement of microtubule (MT)-associated Rho-specific guanine nucleotide exchange factor GEF-H1 in the agonist-ind...

PURPOSE Myasthenia gravis demonstrates a distinct predilection for involvement of the extraocular muscles (EOM), and we have hypothesized that this may be due to a unique immunological environment. To assess this hypothesis, we took an unbiased approach to analyze RNA expression profiles in EOM, diaphragm, and extensor digitorum longus (EDL) in rats with experimentally acquired myasthenia gravi...

Causal attribution has been one of the most influential frameworks in the literature of achievement motivation, but previous studies considered achievement attribution as relatively deliberate and effortful processes. In the current study, we tested the hypothesis that people automatically attribute their achievement failure to their ability, but reduce the ability attribution in a controlled m...

Environmental deformations and changes put countries under socioeconomic stress at the global level are, therefore, an essential topic of discussion. In this context, paper analyzes impact financial development, tourism, economic growth on three different environmental indicators using second-generation panel data techniques for top ten tourism destinations. This study tests whether there is a ...

We show that the eccentricity of every vertex in an undirected graph on n vertices can be computed in time n expO(k log d), where k is the treewidth of the graph and d is the diameter. This means that the diameter and the radius of the graph can be computed in the same time. In particular, if the diameter is constant, it can be determined in time n expO(k). This result matches a recent hardness...

Let F be a family of graphs. In the F-Completion problem, we are given an n-vertex graph G and an integer k as input, and asked whether at most k edges can be added to G so that the resulting graph does not contain a graph from F as an induced subgraph. It appeared recently that special cases of F-Completion, the problem of completing into a chordal graph known as Minimum Fill-in, corresponding...

We define matching between ventricle and afterload to imply that the ventricle is adapted to its afterload to yield maximum external work output. For the ventricle, this optimal adaption will depend on end-diastolic dimension, heart rate, and contractility. Because contractility is impaired during ventricular failure, we propose that the adaption between ventricle and load is not as good during...