Acute lung injury is a syndrome including acute and persistent lung inflammation with augmented vascular permeability (1). Sepsis is the most common reason for acute lung injury (2,3). The overall mortality rate of acute lung injury has been reported as 25 – 58%, although recent advances in the management of sepsis have been revealed (4,5). Many studies have pointed out the role of antiinflamma...

Introduction Acute lung injury induced by mechanical ventilation [ventilator-induced lung injury (VILI)]is characterized by a particular metabolic profile in the lung and in the systemic compartment [1]. Also, VILI has been associated with an increase in intestinal permeability [2]. We hypothesized that selective decontamination of the digestive tract (SDD) can modulate the metabolic profile as...

Gut injury and loss of normal intestinal barrier function are key elements in the paradigm of gut-origin systemic inflammatory response syndrome, acute lung injury, and multiple organ dysfunction syndrome (MODS). As hypoxia-inducible factor (HIF-1) is a critical determinant of the physiological and pathophysiological response to hypoxia and ischemia, we asked whether HIF-1 plays a proximal role...

BACKGROUND: The effects of the murine monoclonal anti-PcrV antibody Mab166 on acute lung injury induced by Pseudomonas aeruginosa were analyzed in a rat model. METHODS: Lung injury was induced by the instillation of P. aeruginosa strain PA103 directly into the left lungs of anesthetized rats. One hour after the bacterial instillation, rabbit polyclonal anti-PcrV IgG, murine monoclonal anti-PcrV...

Mouse IgG and IgA, with reactivity to dinitrophenol conjugated to carrier protein, have been isolated from myeloma proteins by means of a variety of affinity techniques. The IgA was predominantly in the dimeric form. The in vitro and in vivo biological activities of IgA-containing immune complexes were assessed in the rat. IgA-containing immune complexes were demonstrated, in a dose-dependent m...

High concentrations of oxygen aggravate the severity of lung injury in patients requiring mechanical ventilation. Although mesenchymal stem cells have been shown to effectively attenuate various injured tissues, there is limited information regarding a role for amniotic fluid stem cells (AFSCs) in treating acute lung injury. We hypothesized that intravenous delivery of AFSCs would attenuate lun...

OBJECTIVES Hemorrhagic shock followed by resuscitation (HSR) commonly triggers an inflammatory response that leads to acute respiratory distress syndrome. HYPOTHESIS HSR exacerbates mechanical stress-induced lung injury by rendering the lung more susceptible to ventilator-induced lung injury. METHODS Rats were subjected to HSR, and were randomized into an HSR + high tidal volume and zero po...

background: following pulmonary aspiration of gastric contents, a variety of conditions occurs ranging from the acute inflammatory response (aspiration pneumonitis) to an infectious process (aspiration pneumonia). they cause due to the failure of protecting mechanism of airway patency following poisoning toxicity. methods: patients with acute drug poisoning for assessment of aspiration-induced ...

background: we aimed to reveal the role of cd11b and hypoxia-inducible factors-1alpha (hif-1α) expressions on monocytes and alveolar macrophages of lung tissue, and the levels of serum surfactant protein-d (sp-d) in severe malaria-associated acute lung injury (ali). methods: the c57bl/6 mice were divided into control group, renal malaria group (inoculated with 10 6 plasmodium berghei anka), and...