Seizures is a major toxicity of theophylline. The mechanism of theophylline-induced seizures is not known, but antagonism at adenosine receptors may be a possibility. The effect of pretreatment with different doses of adenosine (100, 500 and 1000 mg/kg, i.p.), and the adenosine A1 receptor agonist N6-cyclopentyladenosine (CPA), 1, 5 and 10 mg/kg, i.p., was studied against seizures induced by th...

A 15-year-old girl was admitted to the emergency room because of a bilateral tonic-clonic seizure. The family reported that episode began with rapid hand movements in front patient’s eyes while staring at sun. patient has history multiple admissions department due similar events since age eight. Most occurrences were associated episodes frustration. review literature shown this type phenomenon,...

'Mah-jong epilepsy' is a rare reflex epilepsy syndrome, manifesting as recurrent epileptic seizures triggered by either playing or just watching mah-jong. We present three patients with this condition and review all the reported cases. Mah-jong-induced seizures can be considered a subtype of cognition-induced epilepsy. Nonetheless, these patients have distinctive clinical and electrophysiologic...

introduction: epilepsy is a chronic neurological disorder in which patients experience spontaneous recurrent seizures and deficiency in learning and memory. although the most commonly recommended therapy is drug treatment, some patients do not achieve adequate control of their seizures on existing drugs. new medications with novel mechanisms of action are needed to help those patients whose sei...

BACKGROUND Despite the increasing number and variety of antiepileptic drugs, nearly 30 % of epileptic patients who receive appropriate medical attention have persisting seizures. Anticonvulsant activity has been demonstrated for different iridoid glycoside-rich plant extracts. This study was designed to investigate the anticonvulsant effects of iridoid glycosides purified from Feretia apodanthe...

The effects of interleukin-2 (IL-2) on various models of experimental epilepsy were studied after intracerebroventricular administration in DBA/2 mice, a strain genetically susceptible to sound-induced seizures. Convulsions were induced by physical stimulus (sound of 109 dB. 12-16 kHz) or by chemical compounds (bicuculline, cephazolin or kainate). The present study demonstrated that human recom...

There is a rise in substance abuse Nigeria and prescription drugs, particularly opioid analgesics, which are increasingly becoming target of abuse. Abuse the opiod tramadol has potential to precipitate seizures. We present 3 cases tramadol-induced seizures presenting at Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife. The three patients were men, aged 22-40 years abused other dru...

this study investigated the anticonvulsant activity and possible mechanism of action of an aqueous solution of dorema ammoniacum gum (dag) which has been used traditionally in the treatment of convulsions.in this study, the anticonvulsant activity of dag was examined using the pentylentetrazole (ptz) model in mice. thirty male albino mice were divided randomly and equally to 5 groups, and pretr...