Building classification models from clinical data often requires labeling examples by human experts. However, it is difficult to obtain a perfect set of labels everyone agrees on because medical data are typically very complicated and it is quite common that different experts have different opinions on the same patient data. A solution that has been recently explored by the research community i...

Heparin was discovered 90 years ago,1 and within 2 decades it was being widely used as an anticoagulant.2 The numerous advantages of heparin lend to its broad use including its immediate onset of action, relatively short half-life ( 60 minutes), simple laboratory monitoring (aPTT), ability to be reversed (using protamine), and low cost. Despite a long experience of using heparin, the counterint...

In this issue of Blood, Krauel and colleagues identify two potential off-label treatments(rivaroxaban, dabigatran) for heparin-induced thrombocytopenia (HIT),and also outline aHIT prevention strategy through disrupting PF4/heparin complexes with low-sulfated heparin; the former approach will be easy to implement, the latter much harder—but potentially more worthwhile

Heparin induced thrombocytopenia is a rare complication of heparin therapy that usually occurs within initial 5 to 10 days of heparin exposure. We present a rare case of delayed onset heparin induced thrombocytopenia that occurred one week after cessation.

Ganciclovir is a nucleoside guanosine analogue that exhibits therapeutic activity against human cytomegalovirus infection, and is primarily excreted via glomerular filtration and active tubular secretion. The adverse effects induced by ganciclovir therapy are generally of a hematological nature and include thrombocytopenia and leukopenia. Low marrow cellularity and elevated serum creatinine hav...