We read with great interest the recent article by Khandelwal et al1. In this excellent study, the authors investigated the baseline 25-hydroxy vitamin D levels in children suffering from intrathoracic tuberculosis and its association with type and outcome of tuberculosis. They concluded that type of intrathoracic tuberculosis or outcome was not affected by 25-hydroxy vitamin D levels in these c...

BACKGROUND Thymoma-associated pure red cell aplasia (PRCA) accounts for a significant proportion of cases of secondary PRCA and immunosuppressive therapy has been reported to be useful in this condition. However, because of its rarity, the long-term response and relapse rates after immunosuppressive therapy are largely unknown, and optimal management of this disorder remains unclear. The aim of...

Despite increasingly successful treatment of pediatric ALL, up to 20% of patients encounter relapse. By current biomarkers, the majority of relapse patients is initially not identified indicating the need for prognostic and therapeutic targets reflecting leukemia biology. We previously described that rapid engraftment of patient ALL cells transplanted onto NOD/SCID mice (short time to leukemia,...

......................................... Received: 17-10-13 Accepted: 19-12-13 Abstract MMX® mesalazine is an enteric formulation of 5-ASA with Multi Matrix technology for delayed and prolonged administration of high doses of mesalazine throughout the colon. Clinical trials have demonstrated its clinical and endoscopic efficacy for inducing remission. At doses of 2.4g to 4.8 g/day (2-4 tablets...

The World Health Organization strongly recommends using daily antituberculosis therapy (ATT) during the intensive phase for HIV infected patients. India has the highest burden of tuberculosis in the world, but HIV infected patients are still receiving intermittent ATT. In this study we compared the mortality in patients who received directly-observed intermittent ATT versus self-administered da...

Recently, modified directly observed therapy (MDOT) has emerged as a promising intervention to address nonadherence for hard-to-reach populations infected with HIV. To date, there are no existing data on MDOT focusing exclusively on African Americans. The present study sought to determine the feasibility of MDOT among 31 HIV-seropositive African American substance users in the South. An outreac...

Modified electroconvulsive therapy (ECT) is most often a day care procedure and requires an induction agent with a rapid onset and emergence. At the same time it should not increase the seizure threshold, or decrease the duration of seizures because the clinical outcome of ECT depends on the duration of seizures. Methohexital seems to be the gold standard [1] for induction of general anaesthesi...

INTRODUCTION Indications for induction therapy is not consensual in living donors. OBJECTIVE The objective of this study was compare no induction with thymoglobulin and basiliximab induction in the incidence of acute rejection in kidney transplantation with living donor. METHODS We select all cases of renal transplantation with living donor performed in Hospital das Clínicas de Botucatu da ...

BACKGROUND Biologics are effective for the treatment of psoriasis. However, treatment outcomes may differ among biologic-naive patients and those switched from previous biological therapies. OBJECTIVES The study's objective was to investigate efficacy and safety of ixekizumab, a high-affinity anti-interleukin-17A antibody, in patients with psoriasis with and without previous exposure to biolo...