Chronic, nonbloody diarrhea may represent a diagnostic challenge in patients with inconclusive findings after standard clinical work-up [1]. In this setting, smallbowel capsule endoscopy (SBCE) has high sensitivity and a favorable clinical impact in assessing the presence of small-bowel mucosal lesions in patients with suspected Crohn’s disease and no obstructive symptoms [1–3]. Very recently, ...

Worldwide, approximately 1.8 million children die from diarrhea annually, and millions more suffer multiple episodes of nonfatal diarrhea. On average, in up to 40% of cases, no etiologic agent can be identified. The advent of metagenomic sequencing has enabled systematic and unbiased characterization of microbial populations; thus, metagenomic approaches have the potential to define the spectru...

AIM to evaluate potential improvement effect for probiotic E. coliNissle 1917 in the management of refractory IBS in an Iranian population. METHODS a double blind placebo controlled approach has been used in the current clinical trial. 139 confirmed IBS patients were included into the study, and were given probiotic E.coli Nissle 1917 for 6 weeks. 11 items Birmingham IBS Symptom Questionnaire...

Among travelers from developed countries who visit developing countries, >60% may experience traveler's diarrhea, accounting for 40,000 travelers daily or >15 million travelers annually. Traveler's diarrhea is often accompanied by other symptoms, most often abdominal cramps. Although the spontaneous cure occurs after a mean of 4 days, a few patients have symptoms for weeks, and it is increasing...

Rotavirus is a leading cause of dehydrating diarrhea and death among infants and children globally, particularly in communities of the developing world. While numerous studies have described the complex relationships among infectious diarrhea, growth faltering, and poverty, the impact of nutritional status on susceptibility to rotavirus diarrhea is not well understood. In a longitudinal study c...

BACKGROUND Although deleterious mutations in interleukin-10 and its receptor molecules cause severe infantile-onset inflammatory bowel disease, there are no reports of mutations affecting this signaling pathway in Japanese patients. Here we report a novel exonic mutation in the IL10RA gene that caused unique splicing aberrations in a Japanese patient with infantile-onset of inflammatory bowel d...

Rifaximin showed moderately high MICs (the MIC at which 90% of the isolates tested were inhibited = 50 microg/ml) for 145 bacterial enteropathogens from patients with traveler's diarrhea acquired in Mexico during the summers of 1997 and 1998. Rifaximin concentrations in stool the day after oral administration (800 mg daily for 3 days) were high (average, 7,961 microg/g), proving the value of th...

Twenty-five strains of enterotoxigenic (tox(+)) Escherichia coli isolated in India, Bangladesh, and the U.S.A. were shown to produce vascular permeability factor (PF) activity as well as diarrheagenic activity. Sixteen strains of non-enterotoxigenic E. coli were found to be PF negative. The PF response elicited by tox(+)E. coli isolated in the U.S.A. from cases of infantile diarrhea was qualita...

Siddha system of medicine is one of the oldest medical system of India. Existed separately in early times. Although this system declined in later years., in the wake of changing mode of life modern medicine, it continued to sustain its influence on the masses Parpam is a group of siddha drugs, which is used in diarrhea, colic, pepticulcer, asthma, chronic cough tuberculosis, etc. During the pre...

Enterotoxigenic Escherichia coli is an important cause of traveler's diarrhea and diarrheal illnesses in children in the developing world. In this presentation we will focus on the main virulence attributes of this pathogenic category of E. coli, and discuss the evolution of studies conducted in our laboratory.