Hypertension is involved in the exacerbation of stroke. It is unclear how blood-brain barrier (BBB) tight-junction (TJ) and ion transporter proteins critical for maintaining brain homeostasis contribute to cerebral infarction during hypertension development. In the present study, we investigated cerebral infarct volume following permanent 4-h middle cerebral artery occlusion (MCAO) and characte...

BACKGROUND Neurological outcomes and behavioral assessments are widely used in animal models of stroke, but assessments in rabbit models are not fully validated. The wryneck model of neurological assessment scores (NAS) was compared to percent infarct volume (%IV) values (infarct volume is a proven clinical indicator of stroke severity) and arterial occlusion localization in three rabbit angiog...

Introduction: Black pepper (Piper nigrum L.) is one of the medicinal plants being used to prevent and manage stroke in Persian Medicine. Current findings support its anti-inflammatory, radical scavenging and neuroprotective characteristics. In this study, we aimed to evaluate role of black pepper on functional and histopathological outcomes of stroke in an animal model of MCAO. Materials and Me...

BACKGROUND Patent foramen ovale (PFO) has been implicated in the pathogenesis of cryptogenic stroke through paradoxical embolization to the cerebral circulation. This study evaluated the relationship between the morphological and functional size of the PFO by echocardiography compared with cerebral infarct volume identified on MRI. METHODS AND RESULTS Patients who were referred to interventio...

OBJECTIVE To evaluate the usefulness of a mismatch between the severity of acute clinical manifestations and the diffusion-weighted imaging (DWI) lesion in predicting early stroke outcome and infarct volume. METHODS One hundred sixty-six patients with a hemispheric ischemic stroke of <12 hours' duration were studied. The NIH Stroke Scale (NIHSS) score and the volume of DWI lesion were measure...

UNLABELLED We used gated SPECT to evaluate the impact of abciximab on the efficacy of myocardial reperfusion in patients with acute myocardial infarction undergoing infarct-related artery stenting. METHODS The Abciximab and Carbostent Evaluation (ACE) trial randomized 400 infarct patients to stenting alone or stenting plus abciximab. One-month (99m)Tc-sestamibi gated SPECT was planned in a su...

BACKGROUND AND PURPOSE Interhemispheric inhibition via the corpus callosum has been proposed as an exacerbating factor in outcome from stroke. METHODS We measured infarct volume and behavioral outcome after middle cerebral artery occlusion in callosotomized rats and acallosal mice. RESULTS Neither callosotomy in rats nor callosal agenesis in mice improved infarct volume or behavioral outcom...

Background and Purpose—Interhemispheric inhibition via the corpus callosum has been proposed as an exacerbating factor in outcome from stroke. Methods—We measured infarct volume and behavioral outcome after middle cerebral artery occlusion in callosotomized rats and acallosal mice. Results—Neither callosotomy in rats nor callosal agenesis in mice improved infarct volume or behavioral outcome af...

Stroke has a major impact worldwide in terms of mortality and morbidity. The aim our research was to determine the effect serum Vaspin level on acute ischemic stroke investigate relationship between level, National Institutes Health Scale (NIHSS) infarct volume. This study carried out 100 patients hospitalized with diagnosis Neurology Department Yakutiye Research Hospital Atatürk University Fac...