Background: Previous studies suggested a link between various infectious pathogens and the development of Alzheimer’s disease (AD), posing question whether could present novel modifiable risk factor. Objective: To assess burden due to clinically apparent infections is associated with an increased AD. Methods: We conducted population-based nested case-control study using United Kingdom Clinical ...

BACKGROUND Concern intensifying that emerging infectious diseases and global environmental changes that could generate major future human pandemics. METHOD A focused literature review was undertaken, partly informed by a forthcoming report on environment, agriculture and infectious diseases of poverty, facilitated by the Special Programme for Tropical Diseases. RESULTS More than ten categor...

For those concerned about disparities in health between rich and poor nations, 1993 was a momentous year. First, the World Bank's World Development Report for 1993, subtitled " Investing in Health " [1], forcefully put forward the thesis that improving the health of the poor is an engine for economic development. This is the case because healthier workers are better able to cope with both the i...

BACKGROUND Disease burden is not evenly distributed within a population; this uneven distribution can be due to individual heterogeneity in progression rates between disease stages. Composite measures of disease burden that are based on disease progression models, such as the disability-adjusted life year (DALY), are widely used to quantify the current and future burden of infectious diseases. ...

Infectious diseases exert a major burden of disease in developing countries with 99% of the global burden of infectious diseases, as measured by DALYs, in low and middle income countries. While better use of existing vaccines would make an appreciable difference, the greatest burden is caused by diseases for which we currently have no vaccines. The picture, especially in children, is dominated ...

BACKGROUND Common variable immunodeficiency (CVID) is a primary immunodeficiency disease characterized by recurrent infections and increased susceptibility to autoimmunity and malignancy. OBJECTIVES This study was performed to estimate the burden of CVID in Iran during 1985-2008 based on incidence, mortality, and disability-adjusted life-years (DALY). METHODS The methods developed by the Wo...