Mammalian interleukin-7 (IL-7) is able to stimulate lymphocyte proliferation and maturation, and reverse immunosuppression. However, whether poultry IL-7 has similar functions remains unclear. Chicken infectious bursal disease virus (IBDV) causes serious immunosuppression in chicken due to virus-induced immune disorder. Whether chicken IL-7 (chIL-7) has the ability to restore the immunity durin...

Submit Manuscript | http://medcraveonline.com Abbreviations: FMD: Foot and Mouth Disease; VIM: Virus Infection Media; DNA: Deoxyribonucleic Acid; RNA: Ribonucleic Acid; BHK2: Baby Hamster Kidney; HEP: Human Epithelial Cell; MDCK: Madin Darby Canine Kidney; MRC: Medical Research Council; 3 Day Transfer; MA: Microbiological Associates; NCCS: National Centre for Cell Science; ATCC: American Type C...

Infectious bursal disease virus (IBDV) is a birnavirus causing immunosuppressive disease in chickens. Emergence of the very virulent form of IBDV (vvIBDV) in the late 1980s dramatically changed the epidemiology of the disease. In this study, we investigated the phylogenetic origins of its genome segments and estimated the time of emergence of their most recent common ancestors. Moreover, with r...