Background We designed a simulation study to assess how the conclusions of a non-inferiority trial (NIT) will change if the observed risk is different from the expected risk. Methods We simulated Weibull distribution time-to-event data with a true hazard ratio (HR) being equal or close to 1. The empirical margins and sample size of a hypothetical trial were chosen based on a systematic review...

In this study, a total of 341 questionnaires were used to analyze the effect hairdressers' multidimensional perfectionism and repetitive thinking on job performance through SPSS 21.0. The results survey are as follows. First, Multidimensional (Self-oriented, Other-oriented, Social imposition) appeared in three dimensions, Repetitive thought (Abstract, Specific) two Job stress (Education, Physic...

Many effective drugs, biologics and devices exist. Because of this, it is often considered unethical to undertake placebo controlled clinical trials to evaluate new treatments. Rather, randomized active control noninferiority trials have become the norm. These trials, however, are accompanied by serious issues including selecting an active comparator, identifying previously run active comparato...

The main purpose of the study is to investigate relationship between characteristics perfectionism and inferiority feeling among university students. In study, correlational descriptive survey models quantitative research methods are applied. Participants include 672 students (with 485 females 187 males) whose average age 21 years. As data collection tools, Frost Multi-Dimensional Perfectionism...