Traumatic brain injury (TBI) is a common reason of brain tissue loss as a result of tumors, accidents, and surgeries. Renewal of the brain parenchyma is restricted by many reasons such as inimical substances produced as the result of trauma and also inflammatory responses. A strong cascade of inflammatory responses begins as a result of TBI which include recalling peripheral leukocytes into the...

objective(s): nowadays, cox- 2 inhibitors such as valdecoxib are removed from the market because of their cardiovascular toxicity and their potential to increase the risk of strokes. in response to this, medicinal chemists have attempted to synthesize new classes of cox-2 inhibitors.   materials and methods: in this study, three novel analogues of thiazolidin-4-ones derivatives 2a-c were synthe...

Purpose: To investigate the therapeutic effect and underlying mechanism of hypaphorine in a cellular model non-alcoholic fatty liver disease (NAFLD).Methods: Palmitic acid (PA) was used to induce NAFLD phenotype hepatocytes. Cell viability apoptosis were evaluated by CCK-8 flow cytometry assays. Inflammatory response measured enzyme-linked immunosorbent assay (ELISA). The on lipid accumulation ...

Lymphocytes and T-cell subsets (CD4+T CD3+T) CD19 B cells play an important role in maintaining the function of immune system. The study showed a clear decrease peripheral lymphocytes patients with COVID-19, reason may be attachment to virus or indirectly due injuries from inflammatory mediators, it lead secretion circulating lung tissue Inflammatory conditions also lymphocytopenia, viral infec...

Abstract Clonal hematopoiesis of indeterminate potential (CHIP) is caused by somatic mutations in hematopoietic stem cells and associates with worse prognosis patients heart failure. Patients harboring CHIP show enhanced inflammation. However, whether these signatures are derived from the relatively low number or indicators systemic pro-inflammatory activation that associated unclear. Here we a...

Seaweeds have caused an emerging interest in the biomedical area, mainly due to their contents of bioactive substances which show great potential as anti-inflammatory, anti-microbial, anti-viral and anti-tumoral drugs. Despite the diversity in quality and quantity of the Mediterranean Tunisian coast flora, with its large contains of marine organisms and seaweeds, most of them have not yet been ...