The first case of recurrent neuritis was published by Eichhorst in 1890 (1). In 1958, Austin (2) described steroid responsiveness, recurrence and cerebrospinal fluid (CSF) protein elevation. Dyck and colleagues (3) described the clinicopathological findings of monophasic progression, steady deterioration, stepwise progression and recurrence, with histologic peripheral nervious system (PNS) infl...

The creatine/phosphocreatine pathway plays a conserved and central role in energy metabolism. Compartmentalization of specific creatine kinase enzymes permits buffering of local high energy phosphates in a thermodynamically favorable manner, enabling both rapid energy storage and energy transfer within the cell. Augmentation of this metabolic pathway by nutritional creatine supplementation has ...

Immune mediated inflammatory anterior segment diseases are variable and their management requires intense immunosuppression. Treatment with topical steroids is associated with serious ocular side effects. In order to overcome the potentially blinding complications of topical steroids, immunomodulatory drugs are being used more frequently. Tacrolimus is a calcineurin inhibitor that induces suppr...

Lampinen, M. 2000.Cytokine-regulated eosinophil migration in inflammatory disorders. Clinical and experimental studies. Acta Universitatis Upsaliensis. Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 971. 60 pp. Uppsala. ISBN 91-554-4849-6. The accumulation of eosinophil granulocytes (EOS) at sites of inflammation is a common feature of asthma, allergic rhinitis an...

The pulse wave velocity (PWV), as an indicator of arterial distensibility, may play an important role in the stratification of patients based on the cardiovascular risk. PWV inversely correlates with arterial distensibility and relative arterial compliance. Decreased arterial distensibility alters arterial blood pressure and flow dynamics, and disturbes coronary perfusion. Systemic immune and i...

Disorders of the hepatobiliary system are relatively common extraintestinal manifestations of inflammatory bowel disease (IBD). These disorders are sometimes due to a shared pathogenesis with IBD as seen in primary sclerosing cholangitis (PSC) and small-duct primary sclerosing cholangitis (small-duct PSC). There are also hepatobiliary manifestations such as cholelithiasis and portal vein thromb...

Linear lichen planus (LP) is a rare dermatologic disease in which lichenoid lesions conform to a blaschkolinear distribution, most commonly on the extremities. Linear discoid lupus erythematosus (DLE) is a cutaneous manifestation of lupus that also conforms to Blaschko’s lines. Blaschkolinear disorders have been shown to result from somatic mosaicism, most recently in nevus sebaceus, epidermal ...

P LAQUE PSORIASIS (PP) AND LICHEN RUBER planus (LP) are inflammatory skin disorders that can sometimes be clinically difficult to differentiate. In these instances, punch biopsy with subsequent histopathologic evaluation is usually needed. Recently, dermoscopy has been reported to be helpful in the distinction between these 2 entities. The lesions in Figure 1 and Figure 2 were plaques located o...

endocannabinoid (ecb) system plays a vital role in responses to stress. moreover, ecb and its receptors cause anti-inflammatory, anti-oxidative and neuroprotective effects by modulating neuronal, glial and endothelial cell functions. a number of studies have demonstrated ecb system notably defects in neurotraumatic and neurodegenerative diseases like epilepsy, tbi, alzheimer’s disease and parki...