Sleep plays a vital role in regulating physiological mechanisms in the human body. Nowadays, by the change of lifestyle and as a consequence of longer work hours and increased accessibility to media, sleep disturbance becomes a common problem in modern society. Many studies demonstrated that sleep disturbance triggers a systemic low-grade inflammation by increasing the level of several cytokine...

Protein is one of the major macronutrients essential in human nutrition. sources especially animal sourced proteins are expensive, thus much work has been carried out to explore alternative protein sources. Seaweeds, or macroalgae, emerging as They rich with an excellent amino acid profile comparable other conventional Seaweed contains bioactive components, such free acids, peptides, lectins, a...

introduction: cytokines are a large group of proteins play a key role in inflammation. down-regulation of pro-inflammatory cytokines has beneficial effect on heart function. propranolol, as a non selective beta-adrenergic blocker, has been extensively used for treatment of many cardiovascular problems such as arrhythmias and heart malfunction. in addition anti-inflammatory effects of propranolo...

sleep plays a vital role in regulating physiological mechanisms in the human body. nowadays, by the change of lifestyle and as a consequence of longer work hours and increased accessibility to media, sleep disturbance becomes a common problem in modern society. many studies demonstrated that sleep disturbance triggers a systemic low-grade inflammation by increasing the level of several cytokine...

Inflammatory bowel disease (IBD) is a chronic condition resulting in impaired intestinal homeostasis. Current practices for diagnosis of IBD are challenged by invasive, demanding procedures. We hypothesized that proteomics analysis could provide powerful tool identifying clinical biomarkers non-invasive diagnosis. Here, the global proteomes from commonly used vitro and vivo models were analyzed...

It has long been known that several types of antioxidants also possess anti-inflammatory properties indicating a strong relationship between inflammation and oxidative stress. Reactive oxygen species (ROS) generated by inflammatory cells not only help to kill pathogens but also act on the inflammatory cells themselves, altering the intracellular redox balance and functioning as signaling molecu...

multiple sclerosis (ms) is a progressive and autoimmune neurodegenerative disease of the central nervous system (cns). this disease is recognized through symptoms like inflammation, demyelination and the destruction of neurological actions. experimental allergic encephalomyelitis (eae) is a widely accepted animal model for ms. eae is created in animals by injecting the tissue of myelin basic pr...

BACKGROUND: Dioscorea alata L. tubers (DA) are suspected to prevent diabetes mellitus (DM) because they have a low glycemic index. However, only few reports about the anti-diabetic effect of DA were reported up date. This study aims analyze consumption on several diabetic biomarkers through in vitro, vivo, and silico analysis.METHODS: In vitro experiments conducted by observing anti-inflammator...

Severe cardiovascular diseases, such as myocardial infarction or heart failure, can alter thyroid hormone (TH) secretion and peripheral conversion, leading to low triiodothyronine (T3) syndrome. Accumulating evidence suggests that TH has protective properties against diseases treatment with effectively reduce damage after (MI). Our aim is investigate the effect of T3 pretreatment on cardiac fun...

The miR‑34a/SIRT1 signaling axis is an important in tumors and diseases. Notably, low SIRT1 expression the intestinal tissues of patients with necrotizing enterocolitis (NEC) has been reported. However, whether as a target to protect intestines during NEC process unclear remains be elucidated. Blood samples were collected from 30 NEC, rat model was used. miR‑34a gene protein levels assayed by q...