Cervical Epidural anesthesia has been employed successfully forvanous types of surgical procedures involving the head and neck and the upper extremities and has been shown to be a safe and effective anesthetic modality. This, however, is the first reported case of thyroidectomy being performed under cervical epidural anesthesia. The biggest advantage to be gained from employing this technique l...

Background: Previously, the authors described a physiologic model for closed-circuit Inhalatlonal anesthesia. The basic version of this system model was clinically validated for iso-flurane. An extended version adopted nonpulmonary elim i­ nation causing a constant fraction o f anesthetic to be irre­ versibly lost. This version improved the accuracy o f the model for enflurane. The m odel's per...

Mechanism of AIDN: The agents lead to damage in the hippocampus and amygdala which leads to learning and memory disturbances subsequently. The γ-aminobutyric acid (GABA)-ergic and glutaminergic neurons have been found to undergo apoptosis due to exposure. Experimental studies have shown that nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activation occurs due to inhalational anesth...

Down's syndrome is the most commonly encountered congenital anomaly in medical practice. These patients are of special concern to medical practice because of their associated problems with regard to respiratory, cardiovascular and other systemic problems. As these patients present for repeated surgeries like dental extraction, facial reconstruction and fixation of cervical spine, these patients...

Intraoperative neurophysiological monitoring (IONM) during corrective spinal surgery is widely used. Because of the possible interference with the recording of evoked potentials by inhalational anesthetics, total intravenous anesthetic (TIVA) regimens have been advocated. TIVA regimens may be difficult to use in pediatric populations due to metabolic factors. We report on the results of multimo...

Taking into account that there are controversial antioxidative effects of inhalational anesthetics isoflurane and sevoflurane and absence of comparison of genotoxicity of both anesthetics in animal model, the aim of this study was to compare DNA damage and antioxidant status in Wistar rats exposed to a single time to isoflurane or sevoflurane. The alkaline single-cell gel electrophoresis assay ...

BACKGROUND Some studies suggest that behavioral complications of cholestasis, such as fatigue and pruritus, may be associated with altered neurotransmission in the brain. Because inhaled anesthetics primarily act on ion channels and receptors on the neuronal cell membrane and alter synaptic transmission in the central nervous system, it is possible that altered sensitivity to inhaled anesthetic...

The molecular pharmacology of inhalational anesthetics remains poorly understood. Despite accumulating evidence suggesting that neuronal membrane proteins are potential targets of inhaled anesthetics, most currently favored membrane protein targets lack any direct evidence for anesthetic binding. We report herein the location of the binding site for the inhaled anesthetic halothane at the amino...

43 44 Despite their importance, the mechanism of action of general anesthetics is still 45 poorly understood. Facilitation of inhibitory GABAA receptors plays an important role in 46 anesthesia but other targets have also been linked to anesthetic actions. Anesthetics are 47 known to suppress excitatory synaptic transmission, but it has been difficult to determine 48 whether they act on the neu...