OBJECTIVES To compare the effectivenesses of three phenytoin-loading techniques. METHODS Patients with subtherapeutic phenytoin concentrations who presented within 48 hours of a seizure were randomized to receive either 20 mg/kg of oral phenytoin (PO), divided in maximum doses of 400 mg every two hours, 18 mg/kg of intravenous phenytoin (IVP) at an initial infusion rate of 50 mg/min, or 18 mg...

recently, in order to increase the efficiency of least squares method in numerical solution of ill-posed problems, the chain least squares method is presented in a recurrent process by babolian et al. despite the fact that the given method has many advantages in terms of accuracy and stability, it does not have any stopping criterion and has high computational cost. in this article, the attempt...