نتایج جستجو برای: insertional translocation

تعداد نتایج: 49544  

2014
Ping Dai Yoshinori Harada Hitoshi Miyachi Hideo Tanaka Satsuki Kitano Tetsuya Adachi Tomoyuki Suzuki Hitoshi Hino Tetsuro Takamatsu

The reprogramming of differentiated cells into induced pluripotent stem cells (iPSCs) can be achieved by ectopic expression of defined transcription factors (Oct3/4, Sox2, Klf4 and c-Myc). However, to date, some iPSCs have been generated using viral vectors; thus, unexpected insertional mutagenesis in the target cells would be a potential risk. Here we report reprogramming of siPSCs (gene silen...

Abasalt Hosseinzaeh Colagar, Saeedeh Ghazaey Zidanloo,

Background: The human AML1 gene, located on chromosome 21, can be fused to the AML1- eight-twenty-one (ETO) oncoprotein on chromosome eight, resulting in a t(8;21)(q22;q22) translocation. Acute myeloid leukemia (AML) associated with this translocation is considered a distinct AML with a favorable prognosis. Due to the various incidences of the translocation, which is associated with geographic ...

John.C. Bell, Taravat Bamdad,

The herpes simplex virus type 1 (HSV-1) tegument protein, VP22 has been reported to have the property of intercellular transport. The previous studies have shown that following expression of a fusion protein containing VP22 it spreads to every cell in a monolayer and concentrates in the nucleus. In spite of these reports, some studies have shown that VP22 trafficking and its nucleus accumulatio...

ژورنال: طب جنوب 2019
Farzaneh , Mohammad Reza, Hasanpour , Mojtaba, Khavari , Maryam, Mohammadi Baghmollaei , Esmat,

Short stature is an important clinical feature of Turner syndrome (TS). In this report, a girl with short stature suspected to have Turner syndrome underwent cytogenetic analysis, which confirmd Turner syndrome by observing sex chromosomal monosomy using the karyotype test. In addition to Turner syndrome, Robertsonian (ROB) translocation t(13;14) was detected. As recommended by a genetic counse...

Alghasi A, Aminasnafi A, Jaseb K, Moeinzadeh L, Noroozi F, Pedram M, Saki Malehi A, Saki N, Salari F, Yousefi H,

Background: Acute lymphoblastic leukemia (ALL) is the most common form of childhood cancer leading to cancer-related death in children. Most infants with ALL harbor recurring structural chromosomal rearrangements that are important initiating events in leukemogenesis but are insufficient to explain the biology and heterogeneity of the disease. Mixed-lineage leukemia-rearrangement (MLL-rearrange...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2002
Adam J Dupuy Karl Clark Corey M Carlson Sabine Fritz Ann E Davidson Karra M Markley Ken Finley Colin F Fletcher Stephen C Ekker Perry B Hackett Sandra Horn David A Largaespada

Transposons have been used in invertebrates for transgenesis and insertional mutagens in genetic screens. We tested a functional transposon called Sleeping Beauty in the one-cell mouse embryo. In this report, we describe experiments in which transposon vectors were injected into one-cell mouse embryos with mRNA expressing the SB10 transposase enzyme. Molecular evidence of transposition was obta...

2012

Heel pain is a common complaint and is often poorly managed. Non-operative treatments are highly effective for the vast majority of patients, and surgery is reserved for recalcitrant cases. The first distinction to make clinically is between plantar heel pain and posterior heel pain. The former is commonly caused by plantar fasciitis. Posterior heel pain: Baxter [1] classified Achilles pain as ...

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