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Autophagy, a process that helps maintain homeostatic balance between the synthesis, degradation, and recycling of organelles and proteins to meet metabolic demands, plays an important regulatory role in cellular senescence and differentiation. Here we examine the regulatory role of autophagy in idiopathic pulmonary fibrosis (IPF) pathogenesis. We test the hypothesis that epithelial cell senesce...
In theory, competitive electricity markets can provide incentives for efficient investment in generating capacity. We show that if consumers and investors are risk averse, investment is efficient only if investors in generating capacity can sign long-term contracts with consumers. Otherwise the uncovered price risk increases financing costs, reduces equilibrium investment levels, distorts techn...
This paper attempts to investigate critical success factors affecting enterprise resource planning systems implementation in a university. This research hypothesizes that each job type (administrators, technical staff, and end-users) has a different perspective in the systems implementation in a university. The ANOVA model is employed for the hypothesis testing. Statistical results show the uni...
38 Studies analyzing compliance with guidelines for clinical practice in numerous syndromes and diseases have proliferated, in a praiseworthy attempt to calibrate the distance that separates theoretical recommendations from the reality of care. Heart failure is not exceptional. In the present number of the journal, García Castelo et al.1 report the results of the INCARGAL study, in which they e...
In this paper a method is presented to automatically detect objects from images with insufficient contrast. Using the edge map by the Canny edge detector as a reference, the corresponding edge structures in the edge map by the zero-crossing edge detector are firstly determined. Then meaningful structures are differentiated with respect to those randomly distributed edge segments and are recover...
Locally testable codes are error-correcting codes for which membership of a given word in the code can be tested probabilistically by examining it in very few locations. A linear code C ⊆ F2 is called sparse if dim(C) = O(log(n)). We say that a code C ⊆ F2 is -biased if all nonzero codewords of C have relative weight in the range ( 1 2 − , 1 2 + ), where may be a function of n. Kaufman and Suda...
BACKGROUND The present status of outpatient treatment of depression in Germany was evaluated with respect to the adherence of general practitioners (GPs) and specialists of psychiatry to clinical practice guidelines. METHODS In total, 488 depressed patients' psychopathology, diagnostic assessment, therapeutic measures and referral frequency were documented at inclusion into study by 43 genera...
Dear Editor, With great interest I read the article by Lehmann and Haux [1] in Methods of Information in Medicine (MIM) and the companion article, published in parallel, by Haux and Lehmann [2] in Applied Clinical Informatics (ACI). The authors, who are the respective editors-in-chief of MIM and ACI, evaluate whether the objective to “bridge the divide between ‘bench research’ and applying what...
38 Studies analyzing compliance with guidelines for clinical practice in numerous syndromes and diseases have proliferated, in a praiseworthy attempt to calibrate the distance that separates theoretical recommendations from the reality of care. Heart failure is not exceptional. In the present number of the journal, García Castelo et al.1 report the results of the INCARGAL study, in which they e...
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