ZIERLER, KENNETH 1;. Hyperpolarisation of muscle by insulin in a glucose-free environment. Am. J. Physiol. ‘97(3) : 524-526. 1959. -In a glucose-free solution, insulin increased resting membrane potential of rat extensor digitorum longus muscle by as much as it had in the presence of glucose. Even in the absence of glucose there was probably net accumulation of potassium by muscle, but the incr...

The increased mortality and morbidity from cardiovascular disease associated with diabetes mellitus (DM) is well known. Patients with DM but no previous myocardial infarction (MI) have a risk of MI similar to that of non-diabetic patients with a previous history of MI, and mortality from acute MI in patients with DM is double that in non-diabetic individuals. Five-year mortality in patients wit...

BURTON, STANLEY D., CARL E. MONDON, AND TADASHI ISHIDA. Dissociation of potassium and glucose e$lux in isolated perfused rat I iver. Am. J. Physiol. 212(2) : 261-266. Ig67.-The dissociation of potassium and glucose movement during glucagon-induced glycogenolysis was studied in the isolated rat liver utilizing a small volume perfusion apparatus. When glucagon was added to a preparation assumed t...

BACKGROUND Adrenaline release and excess insulin during hypoglycemia stimulate the uptake of potassium from the bloodstream, causing low plasma potassium (hypokalemia). Hypokalemia has a profound effect on the heart and is associated with an increased risk of malignant cardiac arrhythmias. It is the aim of this study to develop a physiological model of potassium changes during hypoglycemia to b...

The serum immunoreactive insulin (IRI) concentrations, and glucose dissappearance rate-constants after intravenous glucose administration were measured on admission and during recovery in children suffering from protein-energy malnutrition (PEM). 2. A high potassium intake resulted in a considerable increase in the serum IRI levels early in the treatment period. There was a definite relationshi...

OBJECTIVE Impaired glucose metabolism and insulin sensitivity have been reported in patients with Gitelman syndrome (GS), but insulin secretion and the related mechanisms are not well understood. DESIGN AND METHODS The serum glucose levels, insulin secretion and insulin sensitivity were evaluated in patients with GS (n = 28), patients with type 2 diabetes mellitus (DM) and healthy individuals...

Effects of insulin-like growth factor I (IGF-I) and insulin on glucose and potassium fluxes were examined by measuring transhepatic glucose and potassium balance in isolated perfused rat livers. At 1 nM, both IGF-I and insulin decreased basal glucose release by approximately 64% (P < 0.05). Adrenaline (epinephrine)-stimulated glucose release (42.6 +/- 4.5 micromol/g of liver within 30 min) was ...

Introduction: Aluminum phosphide is one of the most common causes of poisoning in the country. It liberates lethal phosphine gas when it comes in contact either with atmospheric moisture or with hydrochloric acid in the stomach. It mainly attacks the cardiovascular and respiratory systems. Eating even small amounts of this toxin can lead to death. This study reports a case of successful treatme...