Stimulator of interferon genes (STING) functions in the cytosolic DNA-sensing pathway innate immunity mammals. It is activated upon binding cyclic dinucleotide 2?3?-cGAMP, a second messenger produced by enzyme guanosine monophosphate–adenosine monophosphate synthase (cGAS), which acts as receptor for DNA this pathway, and triggers expression interferons other viral stress-induced genes. The anc...

Abstract LKB1-mutant lung adenocarcinoma (LUAD), is an intractable form of cancer. LUAD poor in T-cells and does not respond to checkpoint inhibitor therapy, instead enriched tumor-infiltrating neutrophils (TINs). STING a key innate sensor mediating anti-tumor responses that inhibited LUAD. However, the status signaling if it can be induced TINs antagonize tumors unknown. Here, we developed nov...

We describe here the cloning and characterization of a rat homolog of the chemokine receptor CXCR3. The predicted amino acid sequence of rat CXCR3 contains 367 amino acid residues, sharing 96 and 87% amino acid sequence identity to the murine and human CXCR3, respectively. Among a large panel of chemokines tested, only interferon-inducible protein-10 (IP-10), interferon-gamma-induced monokine, ...

background after treatment cessation, a high prevalence of relapse was reported in chronic hepatitis b (chb) patients in china, especially in nucleot(s)ide analogues (nucs)-experienced patients. re-treatment for these patients remains unsolved. objectives this study aims to evaluate the efficacy of pegylated interferon in hbeag positive patients with exposure to antiviral therapy. patients and ...

Anifrolumab (Saphnelo™), an intravenously administered immunoglobulin G1 kappa monoclonal antibody targeting the type 1 interferon alpha receptor, is effective and generally well tolerated as add-on to standard therapy in adults with moderate severe systemic lupus erythematosus (SLE). reduces overall disease activity patients SLE despite receiving stable standard-of-care treatment, based on tot...

The new world arenavirus Junín virus (JUNV) is the causative agent of Argentine hemorrhagic fever, a lethal human infectious disease. Adult laboratory mice are generally resistant to peripheral infection by JUNV. The mechanism underlying the mouse resistance to JUNV infection is largely unknown. We have reported that interferon receptor knockout mice succumb to JUNV infection, indicating the cr...

Tumor necrosis factor receptor-associated 3 (TRAF3), an adaptor protein, has significant and varying effects on immunity depending cell types. The role of TRAF3 in Madin-Darby Canine Kidney Epithelial (MDCK) resistance to influenza A virus (IVA) remains elusive. In the present study, CRISPR-Cas9 gene editing technology was used construct knockout MDCK cells (MDCK-TRAF3−/−). Hemagglutination ass...