BACKGROUND It has been reported that inflammatory cytokines such as interleukin-8 and 6 (IL-8, IL-6) increase during cardiac surgery and caused postoperative cardiac dysfunction. Therefore, it is important to investigate changes of suppressive cytokines such as IL-10, interleukin-4 (IL-4) and interleukin-1 receptor antagonist (IL-1ra) during cardiac surgery. METHOD Serum levels of cytokines a...

Interleukin-4 (IL-4) and interleukin-10 (IL-10) were evaluated for their ability to inhibit the production of nitric oxide (NO) by interferon-gamma (IFN-gamma)- or lipopolysaccharide (LPS)-activated murine macrophages (RAW 264.7 and J774.2). Macrophages pre-treated with IL-4 and then stimulated with IFN-gamma or LPS showed significant inhibition in their ability to produce NO as measured by nit...

Five ampouled preparations of interleukin-4 (IL-41 have been evaluated by 36 laboratories in 14 countries for their suitability to serve as an international standard for this material in a joint international collaborative study for interleukin-3 (IL-3) and IL-4. The preparations were assayed in a wide range of in vitro bioassays and immunoassays. It is clear from the study that different recom...

AIM: to study the cytokine link of immunity in patients with new coronavirus infection COVID-19 and possibility using these data predict risk lung tissue damage.
 MATERIALS AND METHODS: Patients diagnosed were divided into 4 groups depending on severity disease: 1 asymptomatic patients; 2 damage amount 25%; 3 50%; 75% (according results computed tomography). Immunological studies performed...

Tumor cells were isolated from the bone marrow of seven patients with multiple myeloma and from the peripheral blood of three patients with plasma cell leukemia using Ficoll-Hypaque (FH) density sedimentation followed by immune rosette depletion of T, myeloid, monocytoid, and natural killer (NK) cells. Enrichment to greater than or equal to 93% plasma cells was confirmed with Wright's-Giemsa st...

The aim of the present study was to investigate the effects of cadmium (Cd) (5 and 50 mg Cd/l in drinking water) and ethyl alcohol (ethanol, EtOH) (5 g EtOH/kg b.wt., intragastrically), administered alone or simultaneously, on the concentrations of pro-inflammatory (interleukin-1, IL-1α; interleukin-6, IL-6; tumor necrosis factor-α, TNFα and interferon γ, INFγ) and anti-inflammatory (interleuki...

We report the design and synthesis of an aquacarbonyl Ru(II) dication cis-[Ru(CO)2(H2O)4](2+) reagent for histidine (His)-selective metallation of interleukin (IL)-8 at site 33. The artificial, non-toxic interleukin (IL)-8-Ru(II)(CO)2 metalloprotein retained IL-8-dependent neutrophil chemotactic activity and was shown to spontaneously release CO in live cells.

background: salivary gland tumors are among malignancies that have high recurrence rate. immune responses in salivary gland tumors have not been well elucidated. t helper type 1 (th1) and th2 cytokines have been reported to play a role in the outcome of head and neck cancers. objective: to evaluate the serum levels of interferon gamma (ifn- γ), as the hallmark of th1 cytokines, and interleukin-...

Abstract Background The mechanisms of interindividual susceptibility to respiratory syncytial virus (RSV) are not clearly understood. Viral load (VL), an exaggerated immune response or T-helper 2 (Th2) bias were postulated as playing a role in the severity RSV infection. We aimed analyze VL, cytokine profiles and their association with life-threatening disease (LTD). Methods Prospective cohort ...