نتایج جستجو برای: intermittent drug exposure

تعداد نتایج: 893670  

Journal: :Archives of disease in childhood 2006
S A Oliveria M Saraiya A C Geller M K Heneghan C Jorgensen

BACKGROUND As skin cancer education programmes directed to children and adolescents continue to expand, an epidemiological basis for these programmes is necessary to target efforts and plan for further evaluation. AIMS To summarise the epidemiological evidence on sun exposure during childhood and adolescence and melanoma risk. METHODS A literature review was conducted using Medline (1966 to...

Journal: :Cancer research 2006
Arne van Schanke Gemma M C A L van Venrooij Marjan J Jongsma H Alexander Banus Leon H F Mullenders Henk J van Kranen Frank R de Gruijl

Nevi and melanomas correlate to childhood and intermittent solar UV exposure, xeroderma pigmentosum patients run increased risk, and p16(Ink4a) expression is often lost in malignant progression. To ascertain the effect of these risk factors, pigmented hairless Ink4a/Arf-, Xpa- knockout mice were subjected to various combinations of neonatal [7,12-dimethylbenz(a)anthracene (DMBA) or UVB exposure...

Journal: :Brain research 2002
Bin Wang Fei Luo Xue-Cai Ge Ai-Hua Fu Ji-Sheng Han

We have previously shown with a model of morphine-induced conditioned place preference (CPP) that a brief exposure to footshock stress or a priming dose of morphine could reactivate drug-seeking behavior after a long drug-free period. The present study was designed to examine the possible role of certain brain areas in such a reactivation. After the rats were successfully trained with morphine ...

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