A 52 year-old Filipino male with a past medical history of Hepatitis B and C, who underwent orthotopic liver transplantation in 2009, was admitted three years post-transplant with abdominal pain and lower gastrointestinal bleeding. An upper endoscopy was performed which did not reveal a source of bleeding. On colonoscopy, an ileocecal valve (ICV) ulcer was found and biopsies demonstrated necrot...

Abstract Background Identification and photo-documentation of the ileocecal valve (ICV) appendiceal orifice (AO) confirm completeness colonoscopy examinations. We hypothesized that an artificial intelligence (AI)-empowered solution could help us automatically differentiate anatomical landmarks such as AO ICV from polyps normal colon mucosa. Purpose aimed to develop test a deep convolutional neu...

BACKGROUND AND PURPOSE Ventricular dilation and sulcal enlargement are common sequelae after aSAH. Our aim was to quantify the late ventricular dilation and volumes of the CSF spaces after aSAH and to determine if they correlate with neurologic and cognitive impairments frequently detected in these patients. MATERIALS AND METHODS 3D T1-weighted images needed for volumetry were available in 76...

The effect of intracerebroventricular (icv) injections of beta-amyloid peptide fragments Abeta[15-25], Abeta[25-35], and Abeta[35-25] were examined on synaptic transmission and long-term potentiation (LTP) in the hippocampal CA1 region in vivo. Rats were anesthetized using urethan, and changes in synaptic efficacy were determined from the slope of the excitatory postsynaptic potential (EPSP). B...

Freir, Darragh B., Christian Holscher, and Caroline E. Herron. Blockade of long-term potentiation by b-amyloid peptides in the CA1 region of the rat hippocampus in vivo. J Neurophysiol 85: 708–713, 2001. The effect of intracerebroventricular (icv) injections of b-amyloid peptide fragments Ab[15–25], Ab[25–35], and Ab[35–25] were examined on synaptic transmission and long-term potentiation (LTP)...

The purpose of this study was to evaluate the involvement of central angiotensin II (ANG II) and ANG II type 1 (AT(1)) receptors in systemic release of arginine vasopressin (AVP) and blood pressure regulation during endotoxemia. LPS (150 microg/kg) was injected intravenously 30 min after intracerebroventricular (icv) losartan (50 microg), an AT(1) receptor antagonist, or subcutaneous (sc) capto...

Ghrelin, a circulating growth hormone-releasing peptide derived from the stomach, stimulates food intake. The lowest systemically effective orexigenic dose of ghrelin was investigated and the resulting plasma ghrelin concentration was compared with that during fasting. The lowest dose of ghrelin that produced a significant stimulation of feeding after intraperitoneal injection was 1 nmol. The p...

Oxyntomodulin (OXM) is a product of proglucagon processing in the intestine and the central nervous system. We reported that intracerebroventricular (ICV) and intranuclear administration of OXM caused an inhibition of food intake in rats (Dakin CL, Gunn I, Small CJ, Edwards CM, Hay DL, Smith DM, Ghatei MA, and Bloom SR. Endocrinology 142: 4244-4250, 2001). In this study, we investigated the eff...

In the present study, the effects of intracerebroventricular (ICV) administration of normal saline (control), histamine, mepyramine (a histamine H1-receptor antagonist) and ranitidine (a histamine H2-receptor antagonist) were investigated on the formalin-induced pain in rabbits. Subcutaneous (SC) injection of a formalin (100 μl, 5%) solution into the ventral surface of the right hind paw was pe...