In 1959 Swenson and Rathauser described three patients with an unusual dilatation of the colon. Each case had been referred to the hospital with a diagnosis of Hirschsprung's disease (congenital aganglionic megacolon), and on the whole the histories were consistent with this diagnosis. Histological examination of a pre-operative rectal biopsy specimen and a specimen taken during operation, howe...

OBJECTIVE This study was carried out to compare the density of the interstitial cells of Cajal (ICCs) in the bowel wall of children with Hirschsprung's disease (HD), anorectal malformations (ARM) and normal controls in Trinidad and Tobago. SUBJECTS AND METHOD Segments of bowel wall excised from eight children with HD, three controls and two children with ARM were immunostained with c-Kit prim...

Down syndrome (DS) is recognized by characteristic facial features, intellectual disability, and an increased risk for cardiac malformations and duodenal atresia. Recently, Hirschsprung disease (HSCR), or congenital aganglionic megacolon, has been seen more often among patients with DS. Given the systemic nature of DS-related features, it is natural to attribute neonatal complications to the ch...

Congenital aganglionosis rat (AR) is a mutant with an autosomal recessive gene (sl), which shows megacolon caused by the absence of myenteric ganglion cells and white coat-color with a small pigmented spot on the head. Recently, targeted disruption of the endothelin-B (ETB) receptor gene (EDNRB) in the mouse has been reported to cause aganglionic megacolon and coat color spotting resembling the...

context bowel obstruction is one of the most common causes of acute abdomen. because of heterogeneity of patients’ population and variety of causes, therapeutic strategies are not standardized, so treatment of intestinal obstruction is a surgical challenge in many cases. a traditional medicine approach could help detect some issues that were ignored by modern medicine. one of the major schools ...

intestinal stem cells (iscs) are a group of rare cells located in the intestinal crypts which are responsible for the maintenance of the intestinal homeostasis and intestinal regeneration following injury or inflammation. lineage tracing experiments in mice have proven that iscs can repopulate the entire intestinal crypt. it is noteworthy that in such experiments, only a subset of intestinal cr...

background malnutrition and infections are widespread in almost all developing countries. the aim of this study was to investigating prevalence and some of the determinants of malnutrition and intestinal parasitic infections among preschool children in shahroud, iran. materials and methods at across-sectional study, the all preschool children (1,850 cases), in shahroud city as simple census, we...

ventriculoperitoneal (vp) shunt placement that diverts the cerebrospinal fluid (csf) into the peritoneal cavity is the most common method of treatment of hydrocephalus. this shunt has a high incidence of malfunction mainly due to catheter obstruction or infection. about 20% of these complications are abdominal that may occur at any time after shunt placement from 1 week to several years. this s...

background: dog is known to act as definitive host for some parasites that cause important diseases in man and animals. the aim of the present study was to determine the prevalence of neospora caninum and other intestinal parasites in dogs in khorasan razavi province, iran. methods : a cross-sectional study was done concerning frequency of n. canium and other in­testinal parasites in dogs in ma...