Mitochondrial disorders (MIDs) due to respiratory-chain defects or nonrespiratory chain defects are usually multisystem conditions [mitochondrial multiorgan disorder syndrome (MIMODS)] affecting the central nervous system (CNS), peripheral nervous system, eyes, ears, endocrine organs, heart, kidneys, bone marrow, lungs, arteries, and also the intestinal tract. Frequent gastrointestinal (GI) man...

T case was notable because the initial presentation of Crohn’s disease consisted only of extraintestinal manifestations. This is uncommon, and the vast majority of children will present with the typical combination of abdominal pain, diarrhea and weight loss with or without extraintestinal manifestations (Box 1). Extraintestinal manifestations occur in about 25%–35% of cases of inflammatory bow...

Introduction: Inflammation of the genital tract caused by a bacterial infection can affect frequency occurrence hyperproliferative formations uterus, which in turn lead to infertility. Changes microbiota vagina and intestines contribute formation critical problems for women’s reproductive health. Material methods: Microbiota composition was studied using microscopic cultural bacteriological met...

Arthritis and arthralgia are the most common extra-intestinal manifestations of Inflammatory Bowel Disease (IBD), occurring in up to a third of patients. These may affect the peripheral or axial skeletal system and may or may not reflect disease activity. As a result, it is challenging to identify an alternative diagnosis to account for joint manifestations in the setting of IBD. We describe a ...

Hepatic manifestations of the metabolic syndrome are related obesity, type 2 diabetes/insulin resistance and non-alcoholic fatty liver disease. Here we investigated how the anti-inflammatory properties of lactoferrin can protect against the onset of hepatic manifestations of the metabolic syndrome by using a murine model administered with high-fructose corn syrup. Our results show that a high-f...

AIM To assess anti-neuronal antibodies (NA) prevalence and their correlation with neurological disorders and bowel habits in celiac disease (CD) patients. BACKGROUND Neurological manifestations are estimated to occur in about 10% of celiac disease patients and NA to central nervous system (CNS) and enteric nervous system (ENS) are found in a significant proportion of them. Little is known abo...

Henoch-Schonlein purpura (HSP) is a leukocytoclastic vasculitis mediated by IgA deposition that occurs mostly in children. This report describes a young woman with HSP, who presented with cutaneous and gastrointestinal manifestations of this disease. Endoscopy revealed deep annular ulcerations in the terminal ileum and ileocecal valve regions, as well as diffused erythema throughout the gastroi...

A review of recent investigations into pathogenesis of psoriasis summarizing data on the relationship between the presence beta-streptococci in the organism and the cutaneous immune reaction. Results of the studies on gastrointestinal pathology in psoriatic patients are presented. The authors propose a hypothesis that advocates the primary origin of psoriatic gastrointestinal pathology and seco...

A 94-year-old female with end-stage renal disease presents with fever, fatigue, and hematochezia. She had previously resided in Hunan Province, China, and Myanmar, and she immigrated to Taiwan 30 years ago. Colonoscopy revealed a colonic ulcer. Biopsy of the colonic ulcer showed ulceration of the colonic mucosa, and many Paragonimus westermani-like eggs were noted. Serum IgG antibody levels sho...

Infection by human parvovirus B19 is widespread and can be associated with a wide range of different pathologies and clinical manifestations. We provide the first evidence of localization of an active parvovirus B19 infection in the intestinal mucosa and its association with a severe inflammatory bowel disease, characterized by duodenal villous atrophy with increased intraepithelial lymphocytes...