Krabbe disease (KD) is a progressive and devasting neurological disorder that leads to the toxic accumulation of psychosine in white matter central nervous system (CNS). The condition inherited via biallelic, loss-of-function mutations galactosylceramidase (GALC) gene. To rescue GALC gene function CNS twitcher mouse model KD, an adeno-associated virus serotype 1 vector expressing murine under c...

Success in neural tissue transplants at central nervous system suggest that the site may be immunologically privileged. However, this experimental study in which an antigen (Sheep Red Blood Cells) was administered into the third ventricle does not support the above concept. The antibody titre and soluble immune complex levels seen in these animals are similar to the levels seen in animals immun...

The serine protease tissue-type plasminogen activator (tPA) is used as a thrombolytic agent in the management of ischemic stroke, but concerns for hemorrhagic conversion greatly limits the number of patients that receive this treatment. It has been suggested that the bleeding complications associated with thrombolytic tPA may be due to unanticipated roles of tPA in the brain. Recent work has su...

In Parkinson's disease (PD) depletion of dopamine in the nigro-striatal pathway is a main pathological hallmark that requires continuous and focal restoration. Current predominant treatment with intermittent oral administration of its precursor, Levodopa (l-dopa), remains the gold standard but pharmacological drawbacks trigger motor fluctuations and dyskinesia. Continuous intracerebroventricula...

The teleost fish Danio rerio (zebrafish) has a remarkable ability to generate newborn neurons in its brain at adult stages of its lifespan-a process called adult neurogenesis. This ability relies on proliferating ventricular progenitors and is in striking contrast to mammalian brains that have rather restricted capacity for adult neurogenesis. Therefore, investigating the zebrafish brain can he...

We present a new approach to video sequence segmentation into individual shots. Unlike previous approaches, our technique segments the video sequence by combining two streams of information extracted from the visual track with audio track segmentation information. The visual streams of information are computed from the coarse data in a 3-D wavelet decomposition of the video track. They consist ...

this is a field study, tile purpose was to measure and compare the use'. effectiveness and complication of iranian and foreign intra utcrin device ill women who have been using the mentioned method f or birth control ill family planning clinics of the university of medical sciences of iran (/ 993). iii this research by pois son statistical selection, 1620 samples of active record'! oj...

background: different protocols are used for controlled ovarian hyper stimulation (coh), but the optimal method has not yet been determined. objective: the aim of this study was to compare the outcome of controlled ovarian stimulation (cos) using clomiphen citrate (cc) plus hmg versus cc plus rfsh in intra uterine insemination cycles (iui). materials and methods: 144 women with unexplained or m...

intra-abdominal desmoplastic small round cell tumor is a rare entity with a few reports worldwide. this tumor commonly occurs in children and adolescent and occurrence in adult age group is very rare. here, we describe an adult male with symptoms of intestinal obstruction due to abdominal mass, located in splenic flexure. after resection, the diagnosis of intra-abdominal desmoplastic small roun...