INTRODUCTION  Several techniques can be performed to improve nasal tip definition such as cartilage resection, tip grafts, or sutures. Objctive: To evaluate the outcome of lateral intercrural suture at the lower lateral cartilage by endonasal rhinoplasty with a basic technique without delivery in decreasing the angle of domal divergence and improving the nasal tip definition. METHOD  This pro...

OBJECTIVES Delivery of warmed, humidified air via nasal high flow therapy could potentially reduce replication of temperature-sensitive viruses in the upper respiratory tract. This study investigates whether nasal high flow therapy is well tolerated by healthy adults at 37°C and 41°C. METHODS In this randomised, double-blind, controlled crossover pilot trial, nasal high flow therapy was used ...

OBJECTIVES/HYPOTHESIS Sinonasal diseases are often treated with topical agents administered through various application techniques, but few prior studies have examined their distribution to the olfactory mucosa. The purpose of this study was to compare the distribution of nasal irrigations to sprays within the olfactory cleft. STUDY DESIGN Human cadaveric study. METHODS Eight cadaveric head...

Objective(s): Drug delivery via mucosal routes has been confirmed to be effective in inducing strong immune responses. Liposomes could enhance immune responses and mucoadhesive potentials, make them useful mucosal drug delivery systems. Coating of liposomes by mucoadhesive polymers succeeded in enhancing immune responses. Our studies aim at preparation and characterization of trimethylchitosan-...

STUDY OBJECTIVES To determine the optimal method of delivering supplemental oxygen during flexible bronchoscopy (FB). DESIGN Prospective study. SETTING University medical center. PATIENTS Ninety-seven consecutive patients undergoing outpatient nasal FB during a 7-month period. INTERVENTION During FB, delivery of oxygen was alternated weekly and administered by nasal cannula either nasal...

Nasal mucociliary clearance is one of the most important factors affecting nasal delivery of drugs and vaccines. This is also the most important physiological defense mechanism inside the nasal cavity. It removes inhaled (and delivered) particles, microbes and substances trapped in the mucus. Almost all inhaled particles are trapped in the mucus carpet and transported with a rate of 8-10 mm/h t...

Chordomas are dysembryogenic tumors originating from the notochordal process [1] [2]. They are aggressive tumours with unique diagnostic and management challenges. Primary therapy is complete surgical removal of the tumour as much as possible. The likelihood of recurrence is high in spite of complete surgical resection. A 52-year-old female patient presented with complaints of decreased vision ...

The rationale of this study acquaint with improvement of sertraline hydrochloride (STH) solubility, formulation of STH nanoemulsion (NE) for intranasal delivery to achieve rapid onset of action and to omit first pass effect with enhanced bioavailability. STH nanoemulsion (NE) system was formulated consisting of capmul MCM as oil phase, tween 80 as surfactant and propylene glycol as cosurfactant...