Last year marked the ninetieth anniversary of the discovery of insulin by Nobel Laureates Frederick Banting and John Macleod, as well as Charles Best and James Bertram Collip. The initial success of insulin’s ability to lower glucose levels in type 1 diabetes is now shadowed by the urgent need to characterize insulin resistance and secretion defects in type 2 diabetes and obesity. Insulin trigg...

Deferoxamine (DFO) is a high-affinity iron chelator approved by the Food and Drug Administration for treating iron overload. Preclinical research suggests that systemically administered DFO prevents and treats ischemic stroke damage and intracerebral hemorrhage. However, translation into human trials has been limited, probably because of difficulties with DFO administration. A noninvasive metho...

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Shore, S. L., Potter, C. W., and Stuart-Harris, C. H. (1973). Thorax, 28, 721-728. Antibody response to inactivated influenza vaccine given by different routes in patients with chronic bronchopulmonary disease. A comparison was made of the effects of administering inactivated bivalent influenza vaccine to 30 patients with chronic chest disease by various routes. The vaccine was given by subcuta...

Intranasal transmission of hepatitis C virus (HCV) via contaminated drug-sniffing implements is a potential but unconfirmed source of viral infection. We demonstrate the virological plausibility of intranasal transmission by confirming that blood and HCV RNA are present in the nasal secretions and drug-sniffing implements of HCV-infected intranasal drug users recruited from a community health c...

Experiments were performed on carp Cyprinus carpio, rainbow trout Oncorhynchus mykiss, cod Gadus morhua and sturgeon Acipenser ruthenus. An originally designed optico-mechanical system was used to record the response to painful electrical stimulation. before and after administration of analgetic agents. Drugs used were mu agonists tramadol, dermorphine and beta-casomorphine, kappa agonist U-504...

Apnea is a common complication in infants infected by respiratory syncytial virus (RSV). A recent study has shown that intranasal inoculation of RSV in conscious weanling rats strengthens the apneic responses to right atrial injection of capsaicin (CAP), leading to 66% mortality. The objectives of the present study were to determine 1) whether RSV infection changes baseline minute ventilation (...