BACKGROUND Treatment of recurrent pterygium associated with symblepharon usually involves the use of tissue grafting and/or the intraoperative application of mitomycin C (MMC). For the graft, a conjunctival/limbal autograft and/or amniotic membrane may be used. This generally requires extra technical skills and assistance, an increase in the cost and duration of surgery, and a more extensive an...

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AIM To investigate the effect of trabeculectomy with and without mitomycin C in post-keratoplasty glaucoma. METHODS A retrospective study was performed on patients who underwent trabeculectomy for glaucoma after penetrating keratoplasty. 34 eyes of 32 patients were included in this study. 26 eyes received trabeculectomy with mitomycin C and eight eyes without mitomycin C. The procedure was de...

Purpose: The purpose of this study is to reflect anterior segment specialists’ current practice pattern regarding the management primary pterygium. Methods: A 24-item survey indications for surgery, different surgical techniques, use adjuvant pharmacological therapy, type intraoperative and postoperative preferred treatment early recurrences was sent members Saudi Ophthalmological Society (SOS)...

CASE REPORT A 75-year-old man presents for routine follow-up examination 6 years after uncomplicated primary trabeculectomy with a 2minute intraoperative application of mitomycin C (MMC, 0.4mm/ mL). Although progression had occurred when the intraocular pressure (IOP) was in the mid teens, the visual fields have remained stable since filtration surgery was performed. The IOP is 8mm Hg and a lar...

Mitomycin C reduced with sodium borohydride Induced the DNA damage at deoxyguanosines preferentially in dinucleotide sequence G-T. The DNA damage produced strand breaks when subsequently heated. The DNA damage scarcely occurred when the end-labeled DNA was preincubated with ethidium brotmde or actinomycin D before the addition of mitomydn C and the reducing agent. Fully reduced mitomycin C did ...

Agents commonly used in the treatment of neoplastic diseases may impair pulmonary function, and a wide spectrum of agents are currently implicated as toxic to the pulmonary system. Agents most commonly implicated are bleomycin, carmustine, busulfan, methotrexate, and thoracic radiotherapy. Less commonly implicated agents include mitomycin, procarbazine, melphalan, chlorambucil, and cyclophospha...

PURPOSE OF REVIEW To present a review of the current literature regarding the management of glaucoma-filtering bleb infections. RECENT FINDINGS With the increased use of intraoperative antifibrotic (eg, mitomycin and fluorouracil) as an adjunct to standard trabeculectomy, an increased incidence is seen of late-onset filtering bleb-related infections. These infections range from infections loc...

The role of DT-diaphorase in bioreductive activation of mitomycin C was examined using HT-29 and BE human carcinoma cells which have high and low levels of DT-diaphorase activity, respectively. HT-29 cells were more sensitive to mitomycin C-induced cytotoxicity than the DT-diaphorase-deficient BE cell line. Mitomycin C induced DNA interstrand cross-linking in HT-29 cells but not in BE cells. Bo...