We describe a modification of receptor theory that enables the estimation of relative affinity constants for the inactive state of a G protein-coupled receptor. Our approach includes the traditional parameters of observed affinity (K(obs)) and efficacy (fraction of ligand-receptor complex in the active state, ε) and introduces the concept of the fraction of the ligand-receptor complex in the in...

In studies preceding this project we have documented [1, 2, 3] the relationship between the high lET radiationinduced mitotic delay and the expression of chromosome damage. In particular, a direct correlation between the average time to enter the mitosis and aberration burden has been claimed [3]. To further elucidate the complexity of cell cycle arrest after exposure to high LET irradiation, w...

Abstract We revisited the problem of modeling a publicity campaign in society intelligent agents that form their opinions by interchanging information with each other and as whole. use Markov approximation to consider effects an interaction delay $$\tau $$ τ system perturbed differential equations model socia...

This paper is concerned with oscillation of the second-order half-linear delay dynamic equation (r(t)(x)) + p(t)x(τ(t)) = 0, on a time scale T where 0 < γ ≤ 1 is the quotient of odd positive integers, p : T → [0,∞), and τ : T → T are positive rd-continuous functions, r(t) is a positive and (delta) differentiable function, τ(t) ≤ t, and lim t→∞ τ(t) = ∞. We establish some new sufficient conditio...

We obtain the characteristic correlation time associated with a model stochastic differential equation that includes the normal form of a pitchfork bifurcation and delayed feedback. In particular, the validity of the common assumption of statistical independence between the state at time t and that at t-τ, where τ is the delay time, is examined. We find that the correlation time diverges at the...

In this paper, we shall consider higher order nonlinear neutral delay differential equation of the type [x(t) + p(t)x(τ(t))] + q(t) [x(σ(t))] = 0, t ≥ t0, n ∈ N, (*) where p ∈ C ([t0,∞) ,R) is oscillatory and lim t→∞ p(t) = 0, q ∈ C ( [t0,∞) ,R ) , τ, σ ∈ C ([t0,∞) ,R), τ(t), σ(t) < t, lim t→∞ τ(t) = lim t→∞ σ(t) =∞ and α ∈ (0,∞) is a ratio of odd positive integers. If α ∈ (0, 1), equation (*) ...

Emission-line regions in active galactic nuclei (AGNs) and other photoionized nebulae should become larger in size when the ionizing luminosity increases. This ‘breathing’ effect is observed for the Hβ emission in NGC 5548 by using Hβ and optical continuum light curves from the 13-yr (1989–2001) AGN Watch monitoring campaign. To model the breathing, we use two methods to fit the observed light ...

abstract: this paper is the first study on the impact of ambient temperature on the electrical characteristics and high frequency performances of double gate armchair graphene nanoribbon field effect transistor (gnrfet). the results illustrate that the gnrfet under high temperature (ht-gnrfet) has the highest cut-off frequency, lowest sub-threshold swing, lowest intrinsic delay and power delay ...

The nonlinear neutral differential equation x′ (t) = −a (t) g (x (t− τ (t))) + c (t)x′ (t− τ (t)) , with variable delay τ (t) ≥ 0 is investigated. We find suitable conditions for τ , a, c and g so that for a given continuous initial function ψ a mapping P for the above equation can be defined on a carefully chosen complete metric space S0 ψ in which P possesses a unique fixed point. The final r...

In his earlier paper [5] the author considered the n-dimensional stochastic differential delay equation dx t = f x t x t − τ t dt + g x t x t − τ t dB t (1.1) on t ≥ 0 with initial data x θ −τ ≤ θ ≤ 0 = ξ ∈ C 0 −τ 0 R . Here B t = B1 t Bm t T was an m-dimensional Brownian motion defined on the complete probability space t t≥0 with a filtration t t≥0 satisfying the usual conditions (i.e., right ...