BACKGROUND Nucleic acid amplification testing is recommended for screening blood donations; however, they are not widely available in developing countries such as Iranian. Confidential unit exclusion (CUE) gives blood donors the opportunity to confidentially indicate whether their blood is or is not suitable for transfusion to others. Hoewever, its effectiveness in improving blood safety has re...

The adequacy and safety of blood transfusion in sub-Saharan Africa is the subject of much concern, yet there have been very few studies of its history. An overview of that record finds that transfusions were first reported in Africa (sub-Saharan and excluding South Africa) in the early 1920s, and organized transfusion practices were established before the Second World War. Blood transfusion gre...

World Health Organization. External quality assessment of transfusion laboratory practice: guidelines on establishing an EQA scheme in blood group serology.

background blood transfusion is one of the many ways, through which toxoplasma gondii (t. gondii), a protozoan parasite, can be transmitted to humans. objectives this cross sectional study aimed to evaluate the seroprevalence of toxoplasma infection and related epidemiological features among healthy blood donors. materials and methods a total of 375 blood samples from donors were tested for spe...

conclusions: hydroxyurea can be safely used in some transfusion-dependent β-thalassemia patients to decrease their transfusion needs. background: β-thalassemia is an inherited hemoglobin disorder caused by defective synthesis of ß-globin chains. hemoglobin (hb) f induction is a possible therapeutic approach which can partially compensate for α and non-α globin chains imbalance. objectives: we a...

conclusions the analysis indicates that the hev isolated from blood donors in the southwest of iran belongs to genotype 1. however, more samples from other geographic regions of iran are needed to confirm these findings. because transmission of hev by administration of blood or blood components is likely to occur, it may be sensible to screen donor blood for hev to eliminate transfusion-transmi...

Background and Aims: Ficolins are proteins that bind to carbohydrates, act as opsonins and play an important role in innate immunity. Polymorphism in ficolin-3 gene (FCN3) can lead to complement deficiency and increase the risk of some disorders such as diabetes. The aim of this study was to investigate the frequency of FCN3+1637delC as a single nucleotide polymorphism in this gene in healthy a...

background and objectives: laboratory reference values are an important tool for clinical management of patients. reference values being used in most laboratories in iran have been provided from the established reference values from developed countries. however, several variables can affect on these laboratory parameters. therefore, this study was carried out to establish the reference values o...