نتایج جستجو برای: irf7
تعداد نتایج: 556 فیلتر نتایج به سال:
The transcription factor NR4A1 has emerged as a pivotal regulator of the inflammatory response and immune homeostasis. Although contribution of NR4A1 in the innate immune response has been demonstrated, its role in host defense against viral infection remains to be investigated. In the present study, we show that administration of cytosporone B (Csn-B), a specific agonist of NR4A1, to mice infe...
Recognition of viral nucleic acids leads to type I and type III IFN gene expression and activation of host antiviral responses. At present, type III IFN genes are the least well-characterized IFN types. Here, we demonstrate that the p38 MAPK signaling pathway is involved in regulating IFN-λ1 gene expression in response to various types of RNA molecules in human moDCs. Inhibition of p38 MAPK str...
Background SLE is a systemic autoimmune disease caused by impaired innate and acquired immune tolerance, resulting in increased Type I IFN (IFN-I) aberrant B cell development, which cGAS TLR 7/8 signaling play critical roles. TLR7/8 signal activated due to the overresponse nucleic acid derived from clearance of apoptotic cells, leads IFN-I production. Activation also development abnormal popula...
Background Characterizing differentially expressed genes (DEGs) of systemic lupus erythematosus (SLE) is necessary to understand immunogenic interactions, and how several key immune were closely associated with the susceptibility SLE. Objectives This study aimed identify DEGs SLE using gene expression-based computational methodologies analyze disease-immune which affect development progression ...
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