Objective(s):The aim of this study was to determine whether technetium (99mTc) uptake is a relevant method for the differential diagnosis of Graves disease and subacute thyroiditis and calculate its cutoff value in case of its relevancy. Methods: A total of 69 patients, who were followed up (>3 months) in our hospital for thyrotoxi...

INTRODUCTION Autoimmunity against the TSH receptor is a key pathogenic element in Graves' disease. The autoimmune aberration may be modified by therapy of the hyperthyroidism. OBJECTIVE To compare the effects of the common types of therapy for Graves' hyperthyroidism on TSH-receptor autoimmunity. METHODS Patients with newly diagnosed Graves' hyperthyroidism aged 20-55 years were randomized ...

PURPOSE To evaluate tear film quality by rose bengal staining and its stability by breakup time, relating with palpebral fissure height and exophthalmos in patients with Graves' ophthalmopathy. METHODS We studied 54 eyes of 27 patients with Graves' ophthalmopathy, either in the inflammatory or in the chronic phase of the disease. The evaluation consisted of tear film qualitative analysis by r...

BACKGROUND The measurement of free thyroid hormone, instead of the total form, is more commonly used in current practice. We aimed to evaluate the usefulness of the ratio of serum free triiodothyronine (FT3, pg/mL) to free thyroxine (FT4, ng/dL) for differentiating Graves' disease from subacute thyroiditis. MATERIALS AND METHODS Medical records of thyrotoxic patients aged >15 years who had me...

We evaluated the determination of serum G-CSF in the diagnosis of granulocytopenia due to methimazole (MMI) in 54 patients with Graves' disease, while they were being treated with MMI, by way of measuring WBC counts and serum levels of G-CSF, thyroid hormones, IgE, and interleukin-2. Serum TSH was measured by immunoradiometric assay, serum G-CSF was done by enzyme immunoassay, thyroid hormones ...

Incidental papillary carcinoma of the thyroid in patients treated surgically for benign thyroid diseases including Graves' disease is a known phenomenon. However, the management of these patients remains an issue of concern and controversy for those who care for them. We report a case of metastatic papillary carcinoma of the thyroid in a patient previously treated for Graves' disease. The subje...

CONTEXT Hyperthyroidism can lead to reduced bone mineral density (BMD) and increased fracture risk particularly in postmenopausal women, but the mechanism behind is still unclear. OBJECTIVE Prospective examination of the influence of thyroid hormones and/or thyroid autoantibodies on BMD in premenopause. DESIGN We have examined 32 premenopausal women with untreated active Graves' disease fro...

A large data set of geochemical data (Sr/Sr, C, dC, and dN) was obtained for a middle Holocene Early Bronze Age Khuzhir-Nuge XIV cemetery ( 4650–3950 cal. BP) in the Baikal region of Siberia. This material is analyzed at the individual level and in the context of demographic data and spatial arrangements within the cemetery revealing a number of new insights about hunter–gatherer adaptive strat...

AIM The aim of the study was to assess working memory and executive dysfunctions, as well as the intensity of depressive symptoms in hyperthyroid patients with Graves' disease compared to healthy persons. METHOD Thirty (30) patients with Graves' disease (20 female, 10 male), aged 18-55, participated in the study. The control group consisted of 31 healthy persons matched by age, gender and edu...