Bioiron - central to respiration, photosynthesis and DNA synthesis and complicated by radical chemistry with oxygen - depends on ferritin, the super family of protein nanocages (maxi-ferritins in humans, animals, plant, and bacteria, and mini-ferritins, also called DPS proteins, in bacteria) for iron and oxygen control. Regulation of ferritin synthesis, best studied in animals, uses DNA transcr...

No one seems to have attempted to measure the reserve of iron available for haemoglobin synthesis in man. Hahn (1937) estimated that 57 per cent of the total iron in a dog was contained in the blood haemoglobin, 20 per cent was stored in a form potentially available for haemoglobin syn'thesis, and 23 per cent was bound in myohaemoglobin, cell enzymes, etc., and was not available for haemoglobin...

In hereditary hemochromatosis, mutations in HFE lead to iron overload through abnormally low levels of hepcidin. In addition, HFE potentially modulates cellular iron uptake by interacting with transferrin receptor, a crucial protein during erythropoiesis. However, the role of HFE in this process was never explored. We hypothesize that HFE modulates erythropoiesis by affecting dietary iron absor...

Introduction Conventional MR angiography (MRA) exploits the property of exogenous contrast agents to shorten the T1 relaxation time. However, undesirable signal from surrounding tissue due to T1 recovery remains. IRON MRA is a promising off-resonance imaging technique, and provides in conjunction with superparamagnetic nanoparticles high intravascular contrast between the blood-pool and backgro...

In this study, we investigated the cardioprotective effects of resveratrol. Rats were intraperitoneally administered with resveratrol (25 mg/kg bw) or vehicle (ethanol 10%) for 7 days and their heart subjected to ischemia/reperfusion injury. Isolated hearts were langendorff perfused, left ventricular functions as heart rate and developed pressure, as well as, heart antioxidant status were deter...

In this study, we investigated the cardioprotective effects of resveratrol. Rats were intraperitoneally administered with resveratrol (25 mg/kg bw) or vehicle (ethanol 10%) for 7 days and their heart subjected to ischemia/reperfusion injury. Isolated hearts were langendorff perfused, left ventricular functions as heart rate and developed pressure, as well as, heart antioxidant status were deter...

BACKGROUND AND PURPOSE Iron catalyzes the formation of damaging reactive species during cerebral reperfusion. Brain iron concentration is highest at birth, so the brain of the asphyxiated newborn may be at increased risk of iron-dependent injury. We investigated whether the ferric iron chelator deferoxamine could reduce hypoxic-ischemic brain injury in neonatal rats. Because deferoxamine has co...

Pseudomonas aeruginosa produces the siderophore, pyoverdine (PVD), to obtain iron. Siderophore pathways involve complex mechanisms, and the machineries responsible for biosynthesis, secretion and uptake of the ferri-siderophore span both membranes of Gram-negative bacteria. Most proteins involved in the PVD pathway have been identified and characterized but the way the system functions as a who...

Beneficiation of a low-grade iron ore was investigated by combination of the low-intensity magnetic separation and reverse flotation methods. The main constituents of the representative sample were 36.86% Fe, 8.1% FeO, 14.2% CaO, 13.6% SiO2, and 0.12% S based on the X-ray fluorescence, titration, and Leco analysis methods. The mineralogical studies by the X-ray diffraction, scanning electron mi...

A chlorite “hand-bag” belonging to the once-called “intercultural style” production, currently on exhibit in the NationalArchaeological Museum, Tehran, is described focusing attention, for the first time, to the peculiar wear traces clearlyvisible on the handle and along its contour. The strong wear suggests that the hand-bag was suspended for a long time ona cord; and that in this setting it w...