A major consideration in the selection of new and improved iron chelators for clinical use is preferential interaction with the most toxic iron compartment. We describe the biologic properties of a new synthetic hexadentate iron chelator (IRC011) that is a substituted polyaza compound. Unlike deferoxamine (DF ), the polyaza structure of IRC011 does not contain any readily hydrolyzable covalent ...

Accelerated loss of traditional lifestyles may place Inuit at risk of iron depletion given that anemia has been observed among Arctic men. The objectives of this study were to determine the prevalence of anemia, storage iron depletion, and iron overload and to identify correlates of iron status in Canadian Inuit men. In a cross-sectional survey of 994 men in the International Polar Year Inuit H...

Kawamoto and colleagues found that the presence of metabolic syndrome was associated with an increased risk of ischemic stroke (1). However, they did not consider the potential role of elevated iron stores in this setting. Increasing evidence suggests that serum ferritin, a good indicator of body iron stores, is positively associated with metabolic syndrome (2, 3). Furthermore, it has been rece...

The relationship between maternal and foetal iron nutrition has evoked considerable interest and debate. In pregnancy the demand for iron is increased by the mother’s need to expand her red cell mass to fulfill the requirements of the developing foetus. Foetal hon is derived solely from the mother through the active transport function of the placenta, and the quantity transferred might reasonab...

OBJECTIVE Worldwide attention over iron deficiency anemia (IDA) in pregnancy has shifted recently from providing supplements during pregnancy to attempting to ensure that women, especially adolescents, have adequate iron stores prior to conception. We sought to determine whether adolescent and/or adult women still need supplements during pregnancy to avoid IDA, even if iron stores are adequate,...

1. The exchange of iron between plasma and erythroid and non-erythroid tissues was measured in 14 normal subjects, 17 iron-deficient patients, nine patients with primary idiopathic haemochromatosis and in 13 patients with haemolytic disorders. 2. The two main factors determining tissue iron turnover were shown to be the level of iron stores and the erythropoietic activity of the bone marrow.

Although iron is essential for cell replication and survival, an increase of body iron stores has been implicated in the development of cancer. However, while the association between iron overload and hepatocellular carcinoma is well documented, the relationship with nonhepatocellular malignancies remains ill-defined. In this review, we briefly report the present knowledge regarding the associa...