In this paper we observe the extension of the vehicle routing problem (VRP) in fuel delivery that includes petrol stations inventory management and which can be classified as the Inventory Routing Problem (IRP) in fuel delivery. The objective of the IRP is to minimize the total cost of vehicle routing and inventory management. We developed a Variable Neighborhood Search (VNS) heuristic for solv...

Recent developments in urbanization and e-commerce have pushed businesses to deploy efficient systems decrease their supply chain cost. Vendor Managed Inventory (VMI) is one of the most widely used strategies effectively manage chains with multiple parties. VMI implementation asks for solving Routing Problem (IRP). This study considers a multi-product multi-period inventory routing problem, inc...

Yersinia enterocolitica mutant strains, including mutants deficient in the chaperone SycH resulting in a functional deficiency in tyrosine phosphatase (YopH), Mn-cofactored superoxide dismutase (SodA), iron-repressive protein 1 (IRP-1), and Yersinia adhesin A (YadA), were demonstrated to be highly attenuated in wild-type C57BL/6 mice. TNFRp55(-/-), IL-12p40(-/-), and IL-18(-/-) mutant mice, in ...

Ribbon-containing neurons represent a subset of neural cells that undergo graded membrane depolarizations rather than Na(+)-channel evoked action potentials. Bipolar cells of the retina are one type of ribbon-containing neuron and extensive research has demonstrated kinetically distinct pools of vesicles that are released and replenished in a calcium-dependent manner. In this study, we look at ...

In this paper, we present a new mass-flow based Mixed Integer Linear Programming (MILP) formulation for the Inventory Routing Problem (IRP) with explicit energy consumption. The problem is based on a multiperiod single-vehicle IRP with one depot and several customers. Instead of minimizing the distance or inventory cost, the problem takes energy minimization as an objective. In this formulation...

In addition to rods and cones, the human retina contains light-sensitive ganglion cells that express melanopsin, a photopigment with signal transduction mechanisms similar to that of invertebrate rhabdomeric photopigments (IRP). Like fly rhodopsins, melanopsin acts as a dual-state photosensitive flip-flop in which light drives both phototransduction responses and chromophore photoregeneration t...

First, they categorized 37 patients with hypotensive (weak) peristalsis with high integrated relaxation pressure (IRP) as having variant achalasia. However, in the recent Chicago Classification system, high IRP with some instances of intact or weak peristalsis such that the criteria of achalasia are not fulfiled are defined as esophagogastric junction (EGJ) outflow obstruction (2). Thus, in thi...

Robert Haveman, who organized the APPAM session on poverty research, is professor emeritus of economics and public affairs at the University of Wisconsin–Madison and an IRP affiliate; Timothy Smeeding, who organized the APPAM session on poverty policy, is Maxwell Pro-The Institute for Research on Poverty (IRP) at the University of Wisconsin–Madison has reached a unique milestone—forty years as ...

The need for integration in supply chain management leads us to consider the coordination of two logistic planning functions: transportation and inventory. The coordination of these activities can be an extremely important source of competitive advantage in supply chain management. The battle for cost reduction can involve finding the equilibrium between transportation and inventory management ...

BACKGROUND Intraoperative identification of nerve fibers heading from the inferior rectal plexus (IRP) to the internal anal sphincter (IAS) is challenging. The transanal total mesorectal excision (TaTME) is said to better preserve pelvic autonomic nerves. The aim of this study was to investigate the nerve identification rates during TaTME by transanal visual and electrophysiological assessment....