Probiotics have seen widespread use for a variety of gastrointestinal problems, especially in two common disorders: irritable bowel syndrome and inflammatory bowel disease. Since a wide variety of probiotic preparations has been used, and despite a large number of studies performed, a great deal of heterogeneity exists among them. Straightforward evidence-based recommendations for the use of pr...

BACKGROUND AND AIMS Inflammation may play a role in the pathogenesis of irritable bowel syndrome in some individuals, such as in those who develop symptoms following a dysenteric illness. Persisting inflammation, resulting from an imbalance of cytokines regulating the inflammatory response, is one possible mechanism. As the elaboration of cytokines is under genetic control, this study was desig...

BACKGROUND Patients diagnosed with irritable bowel syndrome may have coeliac disease. AIM To evaluate the cost-effectiveness of coeliac disease testing in suspected irritable bowel syndrome. METHODS We used decision analysis to estimate the number of coeliac disease cases detected, quality-adjusted life-years gained, and costs resulting from testing suspected irritable bowel syndrome patien...

Functional bowel disorders (FBDs) are functional gastrointestinal disorders with symptoms attributable to the middle or lower gastrointestinal tract. These include irritable bowel syndrome, functional bloating, functional constipation, functional diarrhea, and unspecified FBD. Increasing evidence has emerged of late that intestinal microbiota is involved in the pathogenesis of FBDs. In this rev...

In the last 3 decades, there has been a growing appreciation for the role of gut bacteria in gastrointestinal disease. Although inflammatory bowel disease and peptic ulcer disease have established a role for gut bacteria for more than 20 years, there is now increasing evidence that intestinal bacteria may play a role in irritable bowel syndrome as well. In this review, the current evidence for ...

since the study period. In-vitro tests of thryoid function have become more specific and more available recently and we believe that these should now be included in the routine investigations whenever there is the slightest suspicion that hyperthyroidism or hypothyroidism might account for a patient's presenting bowel disorder. A total of 57% of the surviving patients (18 men and 26 women) stil...

BACKGROUND We have shown that bran exacerbates irritable bowel syndrome symptoms in a large proportion of secondary-care patients. However, it is unknown if this also happens in primary-care or whether a better response to bran occurs, leading to bran failures being selected for referral to the specialist. AIMS To assess the response to bran in primary-care irritable bowel syndrome comparing ...

BACKGROUND Functional gastrointestinal disorders, including functional dyspepsia, irritable bowel syndrome and functional constipation are very common worldwide. OBJECTIVE This research aims to estimate the prevalence and associated factors involved in functional gastrointestinal disorders in Chinese college and university students using the Rome III criteria. METHODS A total of 5000 studen...

conclusions in conclusion, the persian version of the ibs-qol provided a well-defined measure of qol in ibs patients with high validity and reliability that is an appropriate measure to use in further ibs clinical studies in iran. patients and methods the original 34 items of the ibs-qol were translated from english into persian through a structured procedure for the translation and cultural ad...