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let g=(v,e) be a graph with vertex set v and edge set e.for two vertices u,v of g ,the closed interval i[u,v] ,consists of u,v and all vertices lying in some u-v geodesic in g.if s is a set of vertices of g then i[s]is the union of all sets i[u,v]for u,v ? s. if i[s]=v(g) , then s is a geodetic set for g.the geodetic number g(g) is the minimum cardinality of geodetic set.the maximum cardinalit...
BACKGROUND & OBJECTIVES The quality of life (QOL) of substance abusers is known to be severely impaired. Information on impact of opioid maintenance treatment on the QOL of opioid dependent subjects though available from the developed countries, is lacking from India. This study was carried out to assess the impact of buprenorphine maintenance treatment on the quality of life (QOL) of opioid de...
The effectiveness of modified-directly observed therapy (m-DOT), an adherence support intervention adapted from TB DOTS programmes, has been documented. Describing the implementation process and acceptability of this intervention is important for scaling up, replication in other settings and future research. In a randomised trial in Mombasa, Kenya, patients were assigned to m-DOT or standard of...
Maximum likelihood and related techniques are generally considered the best method for estimating the parameters of spatial models, but exact computation of the likelihood is slow when the number of data points is large. For Gaussian models with parametrically specified covariance function, we consider three alternatives to the exact maximum likelihood estimates that are easier to compute. Stat...
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