purpose: to evaluate the effect of levodopa-carbidopa on improvement of visual acuity, color vision, and visual field in patients with nonarteritic anterior ischemic optic neuropathy (naion) with onset less than 6 wks. methods: in this double-blind randomized controlled trial, 13 patients were treated with levodopa-carbidopa and 12 patients were treated with placebo for 3 weeks. after 6 months,...

introduction: during hemorrhagic shock (hs), the kidneys are one of the primary target organs involved. oxidative stress is shown to be enhanced in different models of acute kidney injury (aki). remote ischemic preconditioning (rpc) by brief limb ischemia is considered to be a safe method to protect different organs from further damage. in this study, we investigated the effects of brief hind l...

purpose : to evaluate the therapeutic effect of posterior sub-tenon methyl prednisolone in anterior ischemic optic neuropathy, no class 1 study has shown any conclusive medical or surgical treatment for non-arteritic anterior ischemic optic neuropathy (naion). efficacy of systemic or intravitreal steroids was suggested by some studies. this study was performed to evaluate the efficacy and safet...

background: in patients with acute ischemic cerebral infarction, thrombolytic therapy using intravenous tissue plasminogen activator (iv?tpa) necessitates precise documentation of symptoms’ onset. the aim of this study was to identify major barriers related to the iv?tpa injection in such patients. materials and methods: between 2014 and 2015, patients with definitive diagnosis of acute cerebra...

background: clopidogrel is one of the most commonly prescribed drugs to prevent ischemic events following coronary syndromes or stent placement. however, impaired responses to therapy as well as resistance are also reported. genetic variants play an important role in clopidogrel biotransformation to its active metabolite that may subsequently influence the clopidogrel antiplatelet effect. the o...

mitochondria play an important role in energy production for the cell. the proper function of a myocardial cell largely depends on the functional capacity of the mitochondria.  therefore it is necessary to establish a novel and reliable method for a non-invasive assessment of mitochondrial function and metabolism in humans. although originally designed for evaluating myocardial perfusion, 99mtc...

conclusions the prevalence of undiagnosed ihd in the hd patients was considerable. we, therefore, suggest that ihd be assessed in hd patients, especially those at high risk due to positive family history of cad, hypertension, left ventricular hypertrophy, diabetes mellitus, kt/v < 1.2, low ferritin levels, and high levels of intact parathyroid hormone. results sixty-nine hd patients were studie...

conclusions lv twist, torsion and untwist and also rate of them are significantly impaired in dcm and this impairment is well-related to lv global systolic and diastolic dysfunction. vvi is a new noninvasive technique that can be used to evaluate lv torsional parameters. results lv twist value (5.54 ± 1.94° in dcm vs. 11.5 ± 2.45° in control group) and also lv torsion (0.71 ± 0.28°/cm in dcm vs...

introduction: we report a 56-year-olds female with supraventricular arrhythmia due acute ischemic stroke without structural heart disease. case description: a patient presented with sudden onset of lethargy, right hemiplegia, and global aphasia. there was previous history of stroke 1 year ago presented with left hemiplegia that recovered completely during 10 days. there was no history of comorb...

introduction: differentiating between ischemic cardiomyopathy (icm) and idiopathic dilated cardiomyopathy (idcm) is important as coronary revascularization can improve prognosis in the ischemic subgroup. due to inherent problems of coronary angiography in patients with depressed ejection fraction (ef) introducing a noninvasive tool to diagnose those who will benefit from angiography seems to be...