نتایج جستجو برای: isocoumarin
تعداد نتایج: 145 فیلتر نتایج به سال:
Antiangiogenic therapy, although effective in shrinking tumors, has not yet been established as a standalone treatment for cancer. This therapeutic limitation can be overcome by combining angiogenesis inhibitors with chemotherapeutic agents. NM-3, a small molecule isocoumarin, is a recently discovered angiogenesis inhibitor. Here we demonstrate that NM-3 inhibits the proliferation of human umbi...
The mechanism-based inactivations of a number of serine proteases, including human leukocyte (HL) elastase, cathepsin G, rat mast cell proteases I and II, several human and bovine blood coagulation proteases, and human factor D by substituted isocoumarins and phthalides which contain masked acyl chloride or anhydride moieties, are reported. 3,4-Dichloroisocoumarin, the most potent inhibitor inv...
Many natural toxins exist in the human environment, which are potentially pathogenic. One of the major groups are mycotoxins produced by some molds. This group includes ochratoxin A (OTA), produced mainly by the strain Aspergillus ochraceus, which commonly occurs in nature and is responsible for rotting of food articles (1, 2). OTA is responsible for the occurrence of many pathologies in the hu...
Chemical conversion of the extract natural resources is a very attractive way to expand chemical space discover bioactive compounds. In order search for new medicines treat parasitic diseases that cause high morbidity and mortality in affected countries world, ethyl acetate from rhizome Alpinia galanga (L.) has been chemically converted by epoxidation using dioxirane generated situ. The biologi...
The number of patients requiring renal replacement therapy due to end-stage renal disease (ESRD) is increasing worldwide. The prevalence of chronic kidney disease (CKD), and the importance of CKD as a risk factor in development of ESRD and in complicating cardiovascular disease (CVD) have been confirmed. In recent years, the involvement of angiogenesis-related factors in the progression of CKD ...
The serine protease hepsin is highly upregulated in prostate cancer and is implicated in tumor progression. Therefore, specific inhibition of hepsin enzymatic activity by an antibody constitutes an attractive therapeutic approach. Here, we report the identification of the anti-hepsin antibody Fab25 by screening of a Fab phage display library with a restricted chemical diversity at the complemen...
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